Nature子刊综述:一文说清p53与肿瘤免疫的关系 p53肿瘤抑制蛋白具有多种细胞功能,已被证明会影响著名的“癌症标志”的每个组成部分。最近的研究开始揭示野生型和突变型p53如何以不同的方式调节肿瘤免疫。今天,小编要和大家分享一篇2024年7月发表在Nature Cancer(...
ArticleADSPubMedCASGoogle Scholar Davis, D. A. et al. Force-induced activation of covalent bonds in mechanoresponsive polymeric materials.Nature459, 68 (2009). ArticleADSPubMedCASGoogle Scholar Geiger, B. & Bershadsky, A. Exploring the neighborhood: adhesion-coupled cell mechanosensors.Cell110, 13...
Pract. 39, 65–78 (2009). PubMed Google Scholar Mandel, N. S., Mandel, I. C. & Kolbach-Mandel, A. M. Accurate stone analysis: the impact on disease diagnosis and treatment. Urolithiasis 45, 3–9 (2017). PubMed Google Scholar Singh, P. et al. Stone composition among first-...
近日,世界知名期刊《Nature》上报道了安德森癌症中心的研究人员通过“CAR-NK”细胞治疗血液肿瘤的I/II期惊艳的临床试验结果,也让人们看到了其在在血液系统恶性肿瘤和难治性实体瘤领域的广阔应用前景! CAR19/IL-15 NK细胞未来可期,1年...
研究者把树突学习[66]和结构可塑性[67]结合起来,把树突的连接数做为一个超参数,以此为学习提供更多的可能。SNN领域的一项互补研究是LSM(liquid state machines)[68]。LSM利用的是未经训练、随机链接的递归网络框架,该网络对序列识别任务表现卓著[ 69–71]。但是在复杂的大规模任务上的表现能力仍然有待提高。
(2009, October). Firefly algorithm for continuous constrained optimization tasks. In International conference on computational collective intelligence (pp. 97-106). Springer, Berlin, Heidelberg. FA - Fireworks algorithm OriginalFA: Tan, Y., & Zhu, Y. (2010, June). Fireworks algorithm for ...
J Global Optim 39(3):459–471 MathSciNet MATH Google Scholar Kashan AH (2009) League championship algorithm: a new algorithm for numerical function optimization. In: 2009 International conference of soft computing and pattern recognition, IEEE, pp 43–48 Kashan AH (2015) A new metaheuristic ...
Yang XS, Deb S (2009) Cuckoo search via Lévy flights. In: World congress on nature and biologically inspired computing, 2009, NaBIC 2009. IEEE, pp 210–214 Mirjalili S (2016) Dragonfly algorithm: a new meta-heuristic optimization technique for solving single-objective, discrete, and multi-...
2009年,Sutherland 等人在 Nature 杂志上报道了以2-氨基恶唑和甘油醛生成阿拉伯糖氨基恶唑啉(AAO)为关键反应的嘧啶核苷酸前生物合成路线( Nature ,2009, 459 , 239)。其中光学纯的AAO可以反应体系中直接结晶得到,AAO和氰基乙炔反应构成嘧啶六元环,但不影响1位β-碳氮糖苷键,从而有效解决了核糖核苷1’ 和2’ 碳...
Nature 459, 824–828 (2009). CAS PubMed Google Scholar Shin, I., Wang, G. & Krische, M. J. Catalyst-directed diastereo- and site-selectivity in successive nucleophilic and electrophilic allylations of chiral 1,3-diols: protecting-group-free synthesis of substituted pyrans. Chem. Eur. ...