et al. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J. 21, 5969–5978 (2002). CAS PubMed PubMed Central Google Scholar deCastro, M. J., Fondecave, R. M., Clarke, L.
The dotted lines assume net CO2 flux into the atmosphere (net emissions minus passive uptake) is reduced linearly to zero in 2050, stabilizing concentrations. The dashed lines show a scenario that follows the same nominal emissions pathway as the solid scenario but assumes that ‘reductions’ are...
minus (g−). Salt bridges in globular proteins are found to favorg+org-configurations. Additionally, the carboxylates of glutamate or aspartate can accept hydrogen bonds via either of the two nonbonded lone pairs of electrons called the syn and anti. Syn carboxylic acid is a weaker acid tha...
Chromosomal instability (CIN) is pervasive in human tumours and often leads to structural or numerical chromosomal aberrations. Somatic structural variants (SVs) are intimately related to copy number alterations but the two types of variant are often stu
The in vivo UPS activity was expressed as the % Ub-M-GFP-positive cells minus the % Ub-R-GFP-positive cells. 26S/30S proteasome purification from human cells Proteasome particles were purified from mammalian cells as described previously89. Human cells were cultured in 15 cm cell culture ...
Transport towards the microtubule minus end (the cilia base). Mother centriole Centrioles are tube-shaped structures composed of nine triplets of microtubules. One of the two centrioles is the mother centriole, which forms the basal body. Polydactyly The formation of additional digits on the li...
Red circles are metabolism-disrupting agents (MDAs). The plus or minus symbol indicates that an MDA can increase or decrease processes and effects; the blocked lines indicate that an MDA can interfere with or block an effect, and the arrows indicate that an MDA can influence a process. KC1:...
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded
YY1 motifs were mainly enriched on the transcript side (the first C of the CCAT sequence occurring on the minus strand at position +12), oriented in a manner that the YY1 protein can position and orient the RNA polymerase II to direct transcription toward the YY motif (Fig. 6d and Houb...
FMO: fluorescence minus one. e, MFI of IFNγ (left) and CD69 (right) in CD8+ cells in sgNT (n = 6 and 6) and sgSlc4a4 (n = 5 and 7) orthotopic KPC1 tumors. f, CD8 staining in sgNT (n = 5) and sgSlc4a4 (n = 6) orthotopic Panc02 tumors. g,h,...