Tea flowerExosome-like nanoparticleBreast cancerMetastasisROS generationMicrobiota modulationIntravenous injectionOral administrationAlthough several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer,their inefficient therapeutic outcomes,serious adverse effects,and high cost...
This study brings new insights to the green production of natural exosome-like nanoplatform for the inhibition of breast cancer and its lung metastasis via i.v. and oral routes. Graphical abstract Exosome-like nanovesicles from edible tea flowers induced mitochondrial damage, cell cycle arrest, cell...
Keywords: Tea flower, Exosome-like nanoparticle, Breast cancer, Metastasis, ROS generation, Microbiota modulation, Intravenous injection, Oral administration, AF633, Alexa Fluor 633-labeled phalloidin, ALP, alkaline phosphatase, ALT, alanine aminotransferase, AST, aspartate aminotransferase, BUN, urea nitro...
(131 nm),exosome-like morphology,and negative zeta potentials.Furthermore,TFENs were found to contain large amounts of polyphenols,flavonoids,functional proteins,and lipids.Cell experiments revealed that TFENs showed strong cytotoxicities against cancer cells due to the stimulation of reactive oxygen ...
immunoaffinity capture, exosome precipitation, size-based and microfluidics-based isolation techniques that have been successfully applied to extract exosome from cells, similar extractive methods based on the characteristics of OMV can be developed (Liet al.2017). There are reasons to believe that with...
Exosome biology could be a new cutting edge at the nano-range research which can be further helpful in cardiovascular diseases, and it seems that they will be generating more reimbursements disproportionate to their size. In this chapter, we discuss the formation, evaluation, drug targeting, and ...
Recently, natural exosome-like nanovesicles were designed (size: 131 nm) from edible tea flowers which remarkably triggered cellular apoptosis of breast tumors and inhibited lung metastasis conditions [80]. Such nanovehicles comprising large amounts of polyphenols, flavonoids, lipids, etc., exhibited ...
We imaged one of the isolates (P9) by cryo-TEM, in which we found no membrane-enclosed vesicles or other types of vesicles of several hundred nanometers; however, there were many small (about 10 nm) electron-dense particles occasionally connected into net-like clusters and many long thin ...
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