In summary, we have isolated exosomes and produced cancer-cell-membrane-exosome-mimetic nanovesicles that both show parent cell targeting. Additionally, homotypic targeting was obtained preferentially by the mimetic nanovesicles.Gabrielle AbbottChuanbin Mao...
4B). In addition, we evaluated the effect of exosome-mimetic nanovesicles in mice without partial hepatectomy. Because no liver injury is present in mice without partial hepatectomy, hepatocytes were in the G0 phase, in which mitotic division is rare or absent. We found that exosome-mimetic NVs...
Exosome-Mimetic Nanovesicles from Hepato- cytes promote hepatocyte proliferation in vitro and liver regeneration in vivo. Sci Rep. 2018;8:2471. 44. Sung BH, Parent CA, Weaver AM. Extracellular vesicles: critical players dur- ing cell migration. Dev Cell. 2021;56:1861–74. 45. Dozio ...
This study aims to explore the targeted efficiency and therapeutic potential of biomimetic platelet membrane-coated exosome-mimetic nanovesicles (P-ENVs) in atherosclerosis.Methods To produce exosome-mimetic nanovesicles (ENVs), MSCs were successively extruded through polycarbonate porous membranes. P-ENVs...
1260Introduction: Exosomes and exosome-mimetic nanovesicles (EV) have found to be effective therapeutics or drug delivery vehicles in a wide range of human diseases including cancer and neurodegenerative diseases (1). In a recent paper, EV derived from pro-inflammatory M1 macrophages could effectively...
Exosomes are naturally secreted nanovesicles that have emerged as a promising therapeutic nanodelivery platform, due to their specific composition and biological properties. However, challenges like considerable complexity, low isolation yield, drug payload, and potential safety concerns substantially reduce ...
therapeutic exosomesAbstract Issues associated with upscaling exosome production for therapeutic use may be overcome through utilizing artificial exosomes. Cellヾerived mimetic nanovesicles (M㎞Vs) ar... 查看全部>>doi:10.1002/pmic.201800161John Wiley & Sons, LtdPROTEOMICS...
Immunomodulatory Effects of MDA-MB-231-derived Exosome Mimetic Nanovesicles on CD4 T Cell Linedoi:10.14744/ejmo.2024.64067Oztatlici, MustafaOzdemir, Alper TungaOztatlici, HulyaKucukhuyuk, SerifeOzdemir, Rabia Bilge OzgulOrhan, HilmiOzbilgin, Kemal...
A method for manufacturing nanovesicles is disclosed. The exosome-mimicking nanovesicle is a nano-sized vesicle contained in the filtrate of adult stem cells that are sequentially passed through two or more membrane filters of different sizes, from the largest filter to the smallest filter. ....
Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemother- apeutics? Nanomedicine (Lond). 2014;9(2):177-80.Jang SC, Gho YS. Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemotherapeutics? Nanomedicine 2014;...