NanocarriersMediated Cutaneous Drug DeliverySevgi GüngrEmine KahramanEuropean Journal of Pharmaceutical Sciences
Recent years more and more research is going on nanotechnology and associated science, which mainly focused on human welfare and clinical field. Different nanocarriers have not only used in targeted drug or nucleotides or proteins delivery, but they also
aSchematic representation of pH-responsive ZIF-8 as a co-delivery system for overcoming MDR for efficient targeted cancer therapy: PEG-FA/(DOX + VER)@ZIF-8 synthesis; accumulation in tumors via EPR effect; internalization via FR-mediated endocytosis; pH-dependent drug release under weak acidic e...
Camouflaging is a technique used in designing the biomimetic dual-drug delivery machines, for example, PLGA NPs loaded with paclitaxel and siRNA targeting HeLa cellular membrane due to multiplied selectivity of the drug for tumor eventually localizes the tumor mediated by immune escaping capacity. In...
A 1.5- to 1.8-fold increase in interleukin-1伪 expression was induced by ME-T compared to the other formulations, but this effect was less pronounced (5.8-fold) than that mediated by the moderate irritant Triton. Because ME-T maximized paclitaxel cutaneous localization while being saf...
Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skinCore-multishell nanocarriersFluorescence lifetime imaging microscopyLangerhans cellsNanoparticle uptakeNanotoxicologyOwing their unique chemical and physical properties core-multishell (CMS) nanocarriers ...
Hung CF, Chen WY, Hsu CY, Aljuffali IA, Shih HC, Fang JY. Cutaneous penetration of soft nanoparticles via photodamaged skin: lipid-based and polymer-based nanocarriers for drug delivery. Eur J Pharm Biopharm. 2015;94:94–105 (PMID: 25986584) ....
Such an accumulation of quercetin in the skin is highly desirable since the efficacy of quercetin in delaying ultra-violet radiation-mediated cell damage and eventual necrosis mainly occurs in the epidermis [38]. 3.4. Nanocarriers for Coenzyme Q10 Delivery Coenzyme Q10 (CoQ10) is the only ...
Stem cells exhibit inflammation-driven tumor tropism mediated by adhesive ligands such as Sialyl Lewis X (SLeX) and P-selectin glycoprotein ligand-1 (PSGL-1). The presence of surface antigens and innate targeting ligands greatly favors their use as tumor-targeted carriers. Currently, stem cells ...
This study shows the potential success of Fe-CHL-mediated PDT for treating melanoma using liposomal delivery systems [41]. In summary, these results show the significance of nanocarriers based delivery methods for improving the therapeutic effectiveness of chlorins derivatives as PS in melanoma PDT ...