In the last decades, efforts have been made on the development of nanocarriers as drug delivery systems to treat VL. Given the preferential intracellular location of the parasite in the liver and spleen macrophages, the rationale is sturdy. In a clinical setting, liposomal amphotericin B displays ...
aThe current review highlights the main advances achieved in utilizing protein nanocarriers as natural vehicles for drug and gene delivery tasks with respect to types,advantages, limitations, formulation aspects as well as the major outcomes of the in vitro and in vivo investigations. 当前回顾突出在运...
Nanocarriers are known to exploit the enhanced permeability and retention (EPR) effect for targeting to tumors thereby increasing tumor drug concentrations while minimizing systemic toxicity. According to the different materials and structures, these carriers can be divided into lipid NPs, polymeric NPs,...
In the recent years, many research efforts have been made to develop drug delivery systems that would prolong the pre-ocular retention and promote the absorption of drugs3,4,5. Nanostructured lipid carriers (NLC), a second generation of solid lipid nanoparticles (SLN), based on mixture of soli...
Nanofillers are fillers with particle diameters between 1 and 100 nm. Examples of such fillers are carbon blacks, synthetic silicas, and precipitated calcium carbonate. Food packaging often uses nanofillers to improve factors including heat and moisture resistance, gas leakage, and packing properties....
When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even
vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in...
(2)Contrast in detail the different means to load drugs and the selection of drug loading means;(3)Discuss multiple ferritin functionalization approaches,together with related advantages and potential risks;and,(4)Compare ferritin with alternative,commonly-used drug nanocarriers.We conclude that despite...
in vaccine development. However, the unique biopharmaceutical hurdles that intranasally or orally delivered protein vaccines need to overcome before they reach the sites of targeting, the relatively low immunogenicity, as well as the low stability of the protein antigens, require thoughtful and fine-...
nanocarrier; (2) Contrast in detail the different means to load drugs and the selection of drug loading means; (3) Discuss multiple ferritin functionalization approaches, together with related advantages and potential risks; and, (4) Compare ferritin with alternative, commonly-used drug nanocarriers....