However, some important drawbacks, including rapid removal from the bloodstream after in vivo administration, or possible replacement, in biological media, of the entrapped drug moieties by other molecules with
Nanocarriers are known to exploit the enhanced permeability and retention (EPR) effect for targeting to tumors thereby increasing tumor drug concentrations while minimizing systemic toxicity. According to the different materials and structures, these carriers can be divided into lipid NPs, polymeric NPs,...
Among different novel drug delivery systems, phytosomes are well-known as biocompatible nanocarriers that have been used to improve solubility and permeability of different phytopharmaceuticals. They are considered as self-assembled nanocarriers that based on phospholipid complexation approach. This type of ...
In the recent years, many research efforts have been made to develop drug delivery systems that would prolong the pre-ocular retention and promote the absorption of drugs3,4,5. Nanostructured lipid carriers (NLC), a second generation of solid lipid nanoparticles (SLN), based on mixture of soli...
in vaccine development. However, the unique biopharmaceutical hurdles that intranasally or orally delivered protein vaccines need to overcome before they reach the sites of targeting, the relatively low immunogenicity, as well as the low stability of the protein antigens, require thoughtful and fine-...
vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains i...
(2)Contrast in detail the different means to load drugs and the selection of drug loading means;(3)Discuss multiple ferritin functionalization approaches,together with related advantages and potential risks;and,(4)Compare ferritin with alternative,commonly-used drug nanocarriers.We conclude that despite...
DRUG stabilityQUANTUM dotsCARBON nanotubesNANOPARTICLESThis review examines recent progress in developing nanoscale drug delivery systems for biomedical applications. Key nanocarriers, including inorganic nanoparticles, dendrimers, protein nanoparticles, polymeric micelles, liposomes, carbon nanotubes (...
Recent progress of targeted nanocarriers in diagnostic, therapeutic, and theranostic applications in colorectal cancer Biomater. Adv., 153 (2023), Article 213556 View PDFView articleView in ScopusGoogle Scholar [3] Y. Wang, Y. Cong, M. Cai, X. Liang, L. Wang, D. Zhou Charge-conversional ...
The advantages of wide availability, high yield, brain tumor-homing ability, inhibition of tumor growth and suppression of angiogenesis make MSCs-derived EVs as superior natural nanocarriers to treat GBM (Liu et al., 2024a, Yuan et al., 2017, Zhang et al., 2020). Secondly, tumor cell-...