DRUG carriersThere is an unmet need for easy‐to‐visualize drug carriers that can deliver therapeutic cargoes deep into solid tumors. Herein, we report the preparation of ultrasmall luminescent imine‐based lanthanide nanocages, Eu60 and Tb60 (collectively Ln60), designed to encapsulate...
While ferritin has been well studied in relation to its physiological properties and mineral core formation, more recently it has been recognized for its potential as a drug delivery vehicle (Fig. 1). Its self-assembly ability, symmetrical spherical architecture, and high thermal stability are impor...
They have several advantages in the development of mRNA delivery systems. First, their surface area and volume can be optimized to achieve desired drug delivery goals such as specific targeting, high capacity for cargo loading, and efficient cellular uptake [9]. Second, PNCs can protect the ...
Biodegradable Covalent Beta‐Cyclodextrin Nanocages for Acidic and Reductive‐Responsive Drug Delivery in Enhanced Tumor Therapy doi:10.1002/biot.70006Biotechnology JournalXiao, JingyiGe, ZanTan, XiaoweiLiu, ZiyiZhang, YafangXiao, ShufenYi, RongyuanHu, YeHu, WenyanChu, HuiChen, Jian...
et al. Ferritin nanocages: a biological platform for drug delivery, imaging and theranostics in cancer. Pharmacol. Res. 107, 57–65 (2016). Article CAS PubMed Google Scholar Wang, Z. et al. Functional ferritin nanoparticles for biomedical applications. Front. Chem. Sci. Eng. 11, 633–646...
for applications in drug delivery, enzyme encapsulation and vaccines4,5,6,7. However, relying on naturally occurring assemblies constrains the engineer to existing sizes, shapes and levels of complexity. Methods for generating new self-assembling proteins render additional classes of structures and ...
exploited for the design of novel functional architectures.5Specific applications of protein nanocages for drug delivery have been discussed in a review by Molinoet al.7and Schoonenet al.8In this review, we focus on natural and synthetic protein scaffolds engineered with specific functional groups ...
The main side effect of these treatments is systemic hemorrhage, which is why alternative approaches or tumor-specific therapeutics are necessary for fibrin treatment in tumors. Recently, Kirtane et al. suggested the impact of fibrin deposits in mediating solid stress and limiting drug delivery to ...
For example, the hollow nanomaterials with porous shells can be used both as nanoreactors for catalytic reaction and nanocontainers for the drug storage and release [56–58]. In addition, the size of NCs can also be effectively controlled by using templates with different sizes. Using Cu2O ...
The advantage of both natural and synthetic protein scaffolds is that they can be exploited for the design of novel functional architectures.5 Specific applications of protein nanocages for drug delivery have been School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore ...