纳米抗体的应用 1,生物医药研发:纳米抗体可用于基因工程药物研发、ADC药物研发等,是一种非常有前景的下一代治疗性抗体技术。 2,疾病诊断与治疗:纳米抗体可用于体外和体内成像,成为疾病诊断的理想选择。同时,其分子质量小、穿透力强,可高效穿透细胞来快速捕获抗原、中和病毒以达到治疗目的。在中枢神经系统疾病、循环系统...
directed ADCs, such as sacituzumab govitecan (IMMU-132), DS-1062, SKB264, ESG-401, DAC-002 and PF-06664178 are all IgG-type monoclonal antibodies, whereas nanobodies have a number of their distinctive advantages that may lead to superior performance of TROP2-directed ADC [9, 12,13,14]...
1,生物医药研发:纳米抗体可用于基因工程药物研发、ADC药物研发等,是一种非常有前景的下一代治疗性抗体技术。 2,疾病诊断与治疗:纳米抗体可用于体外和体内成像,成为疾病诊断的理想选择。同时,其分子质量小、穿透力强,可高效穿透细胞来快速捕获抗原、中和病毒以达到治疗目的。在中枢神经系统疾病、循环系统疾病、感染性疾...
Fig. 4: B7-H3 nanobody-based CAR-T cells effectively lysed PADC and NB cells in vitro. aSchematic showing B7-H3 CAR-T design and production (created with BioRender.com). Lentiviral vectors encode CAR and hEGFRt via a T2A ribosomal skipping sequence, leading to CAR expression on the T ...
to their simpler structure, nanobodies are more stable and easier to produce and engineer, making them ideal building blocks for complex modalities such as cell therapy, bispecific antibody and engager, multi-specific antibody, antibody drug-conjugate (ADC), and radionuclide antibody-conjugate (RAC)...
covering various types of targets and modalities such as monoclonal antibody (RenMab™), bispecific antibody and bispecific ADC (RenLite®), nanobody (RenNano™), TCR-mimic antibody for intracellular targets (HLA/RenMice, i.e., MHC humanized RenMice™), and antibody platform against GPCR...
(Fig.1aand Supplementary Fig.S2). Both 97m and S7 ADC bound to EGFR-positive A431 cells in a concentration-dependent manner, and showed attenuated binding capacity with A431 cells comparing to cetuximab (Fig.1b). However, 97m showed binding with various EGFR mutant cell lines which harbor...
华鼎生物在抗体发现领域深耕多年,具有成熟完善的技术。能够提供抗原制备、羊驼免疫、PBMC分离、cDNA制备、抗体库构建筛选、纳米抗体表达纯化、抗体人源化等一站式服务。 纳米抗体的应用优势 用于临床体外诊断(胶体金法、酶联免疫吸附法、电化学发光法); 用于生物医药研发(基因工程药物研发、ADC药物研发) ...