Nanobody-drug conjugatePancreatic cancerMechanisms of actionAntitumor effectPancreatic cancer is a highly aggressive malignancy with limited treatment options and a poor prognosis. Trophoblast cell surface antigen 2 (TROP2), a cell surface antigen overexpressed in the tumors of more than half of ...
Multivalent anti-EGFR nanobody drug conjugate.aSchematic diagram of 97m and Hydrophobic interaction chromatography (HIC) analysis of S7 ADC.bFlow cytometry analysis of concentration-dependent binding of cetuximab, 97m and S7 ADC with EGFR-positive A431 cells.cBinding ability of biparatopic nanobody ...
drug deliveryFerritin is an iron﹕torage protein nanocage assembled by 24 subunits. The hollow cavity of ferritin enables its encapsulation of various therapeutic agents. Antibody‐ferritin conjugate provides an effective approach for the targeted drug delivery. However, the complicated preparation and ...
ArticlePubMedPubMed CentralGoogle Scholar Wu Y, Li Q, Kong Y, Wang Z, Lei C, Li J, et al. A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors. Mol Ther. 2022;30:2785–99. ArticlePubMedPubMed CentralGoogle Scholar Rowe S...
Pharmacoinformatics-based screening and construction of a neutralizing anti-SARS-CoV-2 camelidae nanobody drug conjugate Elora Kalita Mamta Panda Vijay Kumar Prajapati Molecular Diversity(2025) Recombinant Lactococcus lactis secreting FliC protein nanobodies for resistance against Salmonella enteritidis invasion...
For targeted drug delivery, nanocarriers need to conjugate with targeting ligands, which can specifically recognize and bind to the targets. As one of the most popular targeting ligands, antibody has been widely used owing to its excellent properties (18). However, the application of traditional an...
This deep learning-based prediction approach can greatly accelerate the process of nanobody design, reduce the workload of experimental screening, and offer effective optimization strategies for antibody drug development. 3.5. Validation of the effectiveness of sequence-based structural prediction tools To...
Drug Discovery Today, 21( 7): 1076– 1113. Google Scholar Crossref PubMed WorldCat Stephanopoulos, N., Francis, M. B. ( 2011). Choosing an effective protein bioconjugation strategy. Nature Chemical Biology, 7( 12): 876– 884. Google Scholar Crossref PubMed WorldCat Stone,...
Using a hepatocarcinoma xenograft mouse model (Fig.6h), we found that tumors in the control group (PBS) grew as rapidly as in the blank group (Fig.6i, j). For mice subjected to CTTC injection, tumor volumes decreased 24 h post drug-injection and tumor growth was still inhibited over...
High systemic drug toxicity and increasing prevalence of drug resistance hampers efficient treatment of human African trypanosomiasis (HAT). Hence, development of new highly specific trypanocidal drugs is necessary. Normal human serum (NHS) contains apolipoprotein L-I (apoL-I), which lyses African ...