Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up. Nanoparticles or nanocontainers...
The discovery of nanobodies (Nbs) originated from a class of antibodies (Abs) found in dromedary camels, known as heavy-chain-only antibodies (HCAbs), which lack light chains and CH1 domains. Similar HCAbs have also been identified in cartilaginous fish [1]. This single-domain structure, la...
Our results demonstrate the potential of Nanobodies to target the ligand-binding domain of EphA4. These Nanobodies may deserve further evaluation as potential therapeutics in disorders in which EphA4-mediated signaling plays a role. 展开 关键词: phosphorylation protein-protein interaction receptor-...
Nanobodies as efficient drug-carriers: Progress and trends in chemotherapy 2021, Journal of Controlled Release Citation Excerpt : Since mAbs are post-translationally glycosylated proteins, their functionality has been shown to be dependent on the presence of such glycans [9]. Also, their large and ...
phagocytic clearance. The latter, however, can easily be supplied by genetic fusion of nanobodies to the Fc domains of conventional antibodies, thereby converting nanobodies into a format resembling the original heavy chain antibody21. Nanobodies have potential applications in various disease areas, ...
of approximately 180 and 34 nM (Fig.1b), respectively, showing that they recognize NTCPEMfrom the extracellular side, and suggesting that they stabilize conformational intermediates of the transport cycle. During cryo-EM sample optimization, we screened NTCPEMcomplexes with these nanobodies and meg...
Diverse cell types, including cancer cells, secrete these nano-sized extracellular vesicles. They have garnered substantial attention due to their involvement in intercellular communication, their ability to carry and transfer a variety of bioactive molecules, and their potential applications as both ...
Recently, single-domain antibodies composed solely of the heavy chain variable region (VHH), also known as nanobodies, have been increasingly utilized as alternatives to traditional CAR targeting domains. These nanobodies offer significant advantages, including reduced immunogenicity, enhanced stability and...
Extracellular vesicles are defined as nanosized to microsized particles, delimited by a lipid bilayer membrane, that seem to be released by all cell types and that can transport bioactive molecules between cells, tissues, organs and organisms. Therefore,
Therapeutic potential ofKlebsiellaphages K. pneumoniae-related UTIs have the potential to produce clinical severe problems, including death. For patients who are infected, phages provide an additional therapeutic option. In a past investigation, researchers usedK. pneumoniaeas a host to isolate the phag...