N6-methyladenosine (m6A) methylation is the most abundant RNA internal modification mainly occurring at the consensus motif DR (m6A) CH (D?=?A/G/U, R?=?A/G, H?=?A/C/U) in the 3'-UTR particularly the region near stop codons. The life cycle of m6A methylation includes "writers," ...
RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. ...
m6A RNA methylation regulators can contribute to malignant progression and impact the prognosis of bladder cancer. Biosci. Rep. 39, BSR20192892 (2019). Article CAS PubMed PubMed Central Google Scholar Liu, Q. et al. Molecular characterization and clinical relevance of N6-methyladenosine regulators...
RNA methylationoccurs in different RNA species including tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA-methyltransferases. As a post-translational modification, RNA methylation plays a significant role...
N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer. J Cancer. 2021;12(3):682–92. Article CAS PubMed PubMed Central Google Scholar Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K, Shi H, He C. N(6)-methyladenosine ...
Biomarker Research (2021) 9:39 https://doi.org/10.1186/s40364-021-00295-8 REVIEW Open Access The emerging role of RNA N6- methyladenosine methylation in breast cancer Fangchao Zheng1†, Feng Du2†, Jiuda Zhao3†, Xue Wang4, Yiran Si1, Peng Jin5, Haili Qian6, Binghe Xu1 and ...
Breast cancer is the most common cancer type among women. Despite advanced treatment strategies, some patients still face challenges in disease control, prompting the exploration of new therapeutic approaches.N6-Methyladenosine (m6A) methylation modification regulates RNA and plays a crucial role in vario...
? 2023 Elsevier LtdN6-methyladenosine (m6A) RNA methylation is the most abundant form of mRNA modification in eukaryotes and is at the front line of biological and biomedical research. This dynamic and reversible m6A RNA modification determines the fates of modified RNA molecules at the post-transc...
, such as YTH-domain family proteins and specific RNA binding proteins (RBPs), which mediate the downstream effects of m6A methylation [4]. In plants, the m6A methylation machineries have been characterized in the model plantArabidopsis thalianato modulate development processes such as shoot stem ...
m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 18, 2622–2634 (2017). Article CAS Google Scholar Alarcón, C. R., Lee, H., Goodarzi, H., Halberg, N. & Tavazoie, S. F. N 6-methyladenosine marks primary microRNAs for processing....