RNA N1-甲基腺嘌呤(N1-methyladenosine, m1A)是广泛存在于包括人类在内的真核生物RNA上的翻译后修饰,在甲基化酶和去甲基化酶的催化下,m1A在mRNA和tRNA上呈现动态分布,并通过调控RNA转录和翻译影响细胞功能。人类Fe2+/α-酮戊二酸依赖型双加氧酶家族成员ALKBH3是目前已知的主要RNA m1A去甲基化酶,其功能异常与...
RNA N1-甲基腺嘌呤(N1-methyladenosine, m1A)是广泛存在于包括人类在内的真核生物RNA上的翻译后修饰,在甲基化酶和去甲基化酶的催化下,m1A在mRNA和tRNA上呈现动态分布,并通过调控RNA转录和翻译影响细胞功能。人类Fe2+/α-酮戊二酸依赖型双加氧酶家族成员ALKBH3是目前已知的主要RNA m1A去甲基化酶,其功能异常与...
Background: Recent researches have investigated the biological importance of RNA N1-methyladenosine (m1A) modifications in oncogenesis and progression of head and neck squamous cell carcinoma (HNSCC). However, whether m1A modifications also have latent effect in tumor microenvironment (TME) generation ...
为了深入探讨ADAR1在PH发病机制中的作用,2023年12月,深圳市人民医院Zhang等人在《Acta Pharm Sin B》杂志(2023IF=14.5,当前IF=14.5,医学一区)发表了题为“ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N 1-methyladenosine modification of circCDK17”的文章。 02 所用到的主要方...
N1-Methyladenosine 目录号: 所属分类: 具有重要生物活性的衍生物 应用与生物特性: Application & Biological Property RNA modified nucleoside m1A 在线留言 产品详情 Catalog No. P1049 Name N1-Methyladenosine Synonyms 中文名称 N1-甲基腺苷 Formula C11H15N5O4 FW 281.27 CAS No. 15763-06-1 HPLC...
生物信息学分析显示circCDK17存在多个m1A修饰位点而无m6A修饰位点。进一步的甲基化RNA免疫沉淀实验证明,circCDK17的m1A修饰水平在PH患者肺组织中显著下调,而ADAR1的过表达显著增加了circCDK17的m1A修饰水平。此外,ADAR1沉默逆转了低氧诱...
a given type of RNA modification during reverse transcription, allowing for site-specific identification of the modification. To develop and validate the platform, we evolved the HIV-1 reverse transcriptase againstN1-methyladenosine (m1A). Iterative rounds of selection yielded reverse transcriptases with...
N1-methyladenosine is a unique type of base methylation in that it blocks Watson-Crick base pairing and introduces a positive charge. m1A is prevalent in yeast and mammalian mRNA and plays a functional role. However, little is known about the abundance, dynamics and topology of this modification...
Together, five m1A-related lncRNAs generated a prognostic signature that could be a promising prognostic prediction approach and therapeutic response assessment tool for HCC patients. Keywords: hepatocellular carcinoma (HCC); N1-methyladenosine (m1A); long non-coding RNAs (lncRNAs); prognostic signature...
Here we show that N1-methyladenosine methylation (m1A) in tRNA is remarkably elevated in hepatocellular carcinoma (HCC) patient tumour tissues. Moreover, m1A methylation signals are increased in liver cancer stem cells (CSCs) and are negatively correlated with HCC patient survival. TRMT6 and TRM...