RNA N1-甲基腺嘌呤(N1-methyladenosine, m1A)是广泛存在于包括人类在内的真核生物RNA上的翻译后修饰,在甲基化酶和去甲基化酶的催化下,m1A在mRNA和tRNA上呈现动态分布,并通过调控RNA转录和翻译影响细胞功能。人类Fe2+/α-酮戊二酸依赖型双加氧酶家族成员ALKBH3是目前已知的主要RNA m1A去甲基化酶,其功能异常与...
Name N1-Methyladenosine Synonyms 中文名称 N1-甲基腺苷 Formula C11H15N5O4 FW 281.27 CAS No. 15763-06-1 HPLC ≥ 97% Package Packed as desired Classification 核苷衍生物; 具有重要生物活性的衍生物 Property Appearance and Property: white to off-white solid, hygroscopic, light sensitive m. p.: >...
为了深入探讨ADAR1在PH发病机制中的作用,2023年12月,深圳市人民医院Zhang等人在《Acta Pharm Sin B》杂志(2023IF=14.5,当前IF=14.5,医学一区)发表了题为“ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N 1-methyladenosine modification of circCDK17”的文章。 02 所用到的主要方...
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recen
Regulation of cancerN1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recent years, there has been a ...
Zhang J, Li Y, Zhang J, Liu L, Chen Y, Yang X, Liao X, He M, Jia Z, Fan J, Bian JS, Nie X. ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension throughN1-methyladenosine modification of circ...
N1-methyladenosine is a unique type of base methylation in that it blocks Watson-Crick base pairing and introduces a positive charge. m1A is prevalent in yeast and mammalian mRNA and plays a functional role. However, little is known about the abundance, dynamics and topology of this modification...
we evolved the HIV-1 reverse transcriptase againstN1-methyladenosine (m1A). Iterative rounds of selection yielded reverse transcriptases with both robust read-through and high mutation rates at m1A sites. The optimal evolved reverse transcriptase enabled detection of well-characterized m1A sites and ...
1-Methyladenosine1-甲基腺苷15763-06-1 2'-Fluoro-2'-deoxythymidine2'-氟胸苷2923-73-1 2'-O-methylinosine2‘-甲氧基肌苷3881-21-8 TFA-aa-dC5-TFA-AA-DC96102-27-1 (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl...
转录后修饰广泛存在于非编码RNA和编码RNA上,对RNA正确折叠,结构维持,可变剪接以及翻译调控等过程具有重要作用.tRNA第58位腺嘌呤1位的甲基化修饰(N1-methyladenosine,m... 唐俊,发育生物学 被引量: 0发表: 0年 AtTRN1相互作用蛋白的初步筛选 蛋白质入核转运对于维持细胞正常的生命活动具有极其重要的意义.目前在哺乳...