Previous work has unveiled that the Arg- N -end rule degradation pathway (Arg- N -degron pathway) mediates the degradation of PINK1, and thus fine-tune PINK1-dependent mitochondrial quality control pathway. Herein, we briefly discuss the interconnection between N -end rule degradation pathways and...
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The N-end rule dictates that a protein's N-terminal residue determines its half-life. In bacteria, the ClpS adaptor mediates N-end-rule degradation, by recognizing proteins bearing specific N-terminal residues and delivering them to the ClpAP AAA+ protease. Unlike most bacterial clades, many ...
The N-degron pathway, formerly the N-end rule pathway, is a protein degradation process that determines the half-life of proteins based on their N-terminal residues. In contrast to the well-established in vivo studies over decades, in vitro studies of this pathway, including biochemical characte...
The N-degron pathway (1), formerly the N-end rule pathway, governs the regulation of the in vivo half-life of a protein based on its N-terminal residues (2, 3, 4). It is a universal ubiquitin (Ub)-dependent4 proteolytic system that exists in both prokaryotes and eukaryotes (5, 6,...
The N-degron is an intracellular degradation signal whose essential determinant is a specific, destabilizing, N-terminal amino acid residue. A set of N-degrons containing different destabilizing residues is manifested as the N-end rule, which relates the in vivo half-life of a protein to the...
The N-degron is an intracellular degradation signal whose essential determinant is a specific, destabilizing, N-terminal amino acid residue. A set of N-degrons containing different destabilizing residues is manifested as the N-end rule, which relates the in vivo half-life of a protein to the...
Protein degradationProteasomeN-end ruleN-degronPINK1Among the mostsalient features that underpin the development of aging-related neurodegenerative disorders are the accumulation of protein aggregates and the decrease in cellular degradation capacity. Mammalian cells have evolved sophisticated quality control ...
The N-degron is an intracellular degradation signal whose essential determinant is a specific, destabilizing, N-terminal amino acid residue. A set of N-degrons containing different destabilizing residues is manifested as the N-end rule, which relates the in vivo half-life of a protein to the...
Plants contain a unique combination of N-degron pathways(previously called the N-end rule pathways) E3 ligases, PROTEOLYSIS(PRT)6 and PRT1, recognizing non-overlapping sets of amino-terminal residues,and others remain to be identified. Although only very few substrates of PRT1 or PRT6 have ...