2025年1月7日,中国农业科学院农业资源与农业区划研究所易可可研究员和徐磊副研究员在Plant Communications发表了题为 “The basal level of salicylic acid represses the PRT6 N-degron pathway to modulate root growth and stress response in rice” 的研究论文。该研究揭示了本底水杨酸通过抑制PRT6 N-degron通路...
细胞中蛋白的半衰期通常由称为degrons的短线性序列决定,它们可以募集E3泛素连接酶,泛素化底物并将其靶向蛋白酶体降解。Pro/N-degrons 通路是通过GID4蛋白识别序列第一或第二位含有未修饰脯氨酸残基的N端degrons,随后被称为 GID ...
N-degron和C-degron分别被对应的E3连接酶识别,致使底物蛋白降解的通路就被称为N端降解通路(N-degron pathways)和C端降解通路(C-degron pathways)。 宓文义教授和董城教授两个团队的研究扩展了N端降解通路的分支,他们首先通过多肽阵列芯片技术对ZER...
网络N端降解决定子 网络释义 1. N端降解决定子 ... N-band N 带,核仁组织(区)带N-degronN端降解决定子[决定蛋白质发生降解的N端序列要素]near edge structure 近边结构 ... www.foodmate.net|基于 1 个网页
The N-degron pathway targets proteins that bear a destabilizing residue at the N terminus for proteasome-dependent degradation1. In yeast, Ubr1—a single-subunit E3 ligase—is responsible for the Arg/N-degron pathway2. How Ubr1 mediates the initiation of ubiquitination and the elongation of the...
Pro/N-degrons 通路是通过GID4蛋白识别序列第一或第二位含有未修饰脯氨酸残基的N端degrons,随后被称为 GID 复合物的多亚基 E3 连接酶复合物泛素化,靶向它们进行蛋白酶体降解。该GID复合物在人类中称为CTLH复合物。其中,GID4是唯一已知的底物受体,但某些底物以独立于GID4的方式降解,且GID4结合口袋中的某些...
In our AptaGron system, a peptide nucleic acid containing an N-degron peptide and a sequence complementary to the aptamer was designed. Using this system, we successfully degraded three target proteins, tau, nucleolin, and eukaryotic initiation factor 4E (eIF4E), which lack specific small-molecule...
The ClpS adaptor protein (cyan) binds both N-end-rule substrates (pink) and the ClpA N-terminal domain, which is flexibly attached to the body of ClpA. (B) Structure of C. crescentus ClpS bound to N-terminal Tyr (PDB: 3DNJ). The unstructured N-terminal extension, the N-degron ...
A heat-inducible N-degron module is a protein or peptide bearing a destabilizing N-terminal amino acid residue which becomes a substrate of the N-end rule pathway only at a temperature high enough to result in at least partial unfolding of the protein. At this elevated (nonpermissive) ...
A targeted analysis of NatA substrate stability uncovers that NTA absence triggers protein destabilization via a previously undescribed and widely conserved nonAc/N-degron in plants. Hence, the imprinting of the proteome with acetylation marks is essential for coordinating proteome stability. 展开 关键...