Zhang P, Guo ZF, Xu YM, Li YS, Song JG (2016) N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-kappaB signaling pathway. Biomed Pharmacoth- er 83:658-666.Zhang P, Guo ZF, Xu YM, Li YS, Song JG (2016a) N-Butylphthalide ...
LIU Z,WANG H,SHI X,et al.dl-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway[J].Neurochem Res, 2017,42(5):1375-1386.DOI: 10.1007/s11064-017-2186-z.
NBP affected gene expression of key enzymes of the TCA cycle, as well as protein expression of p-AKT and p-CREB. Our findings provide the first evidence showing that NBP can attenuate stress-induced behavioral deficits by modulating energy metabolism by regulating activation of the AKT/CREB ...
3-n-Butylphthalide (NBP), a pure component extracted from Apium graveolens Linn, was approved by the China Food and Drug Admin... Dec 10,20243-N-Butylphthalide Basic information Product Name: 3-N-Butylphthalide Synonyms: 3-butyl-1(3h)-isobenzofuranon;BUTYLPHTHALIDE, 3-n-(P);3-Butyliso...
DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective effects due to its anti-inflammatory, anti-oxidative and anti-apoptotic activities. DL-NBP not only protects against ischemic cere...
Recent evidence indicates that Dl-3-n-butylphthalide (NBP) has the neuroprotective effect in ischaemic brain injury, but whether it has protective effects on SCI or not is largely unclear. Here, we show that NBP prevented BSCB disruption after SCI via inhibition of ER stress. Following a ...
Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.| Diao, X., et al. 2014. Drug Metab Dispos. 42: 774-81. PMID: 24468743 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia.| Zhao, W....
Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved colourless, oily liquid; warm-spicy herbaceous aroma Butylphthalide is a member of benzofurans.|Butylphthalide has been used in trials studying the prevention of Restenosis.ldentification Cas NO.: 6066-49...
Thus, L-NBP may be a promising therapeutic agent against DM-mediated cognitive dysfunction. 展开 关键词: Apoptosis Cognitive dysfunction Diabetes Inflammation L-3-n-butylphthalide LTP Oxidative stress DOI: 10.1007/s11011-018-0356-6 年份: 2019 ...
L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), has been shown to have neuroprotective effects on cerebral ischemic, vascular dementia and amyloid-β (Aβ)-induced animal models by inhibiting oxidative injury, neuronal apoptosis and glial activation...