用于胺的N-烷基化的方法,其中,醇是在氢存在下与烷基胺或二烷基胺进行反应,反应是在一种以铜和镁的硅酸盐为基并且在每一种情况中独立地含有0～2%重量的BaO,Cr N- alkylation of the amine, wherein the alcohol is reacted in the presence of hydrogen with an alkyl amine or a dialkyl amine, the ...
该反应实用性强:手性配体可以百克级大量合成且无需纯化,可以将复杂药物分子拼接合成孪药等。相关成果以“铜催化烷基胺的立体汇聚式N-烷基化反应(Enantioconvergent Cu-catalyzed N-alkylation of aliphatic amines)”为题,在《自然》(Nature)上发表。化学加今天的次条是该团队刚发的JACS,热烈祝贺! 正文 手性胺在医药...
ChemInform Abstract: N-ALKYLATION OF AMINES AND AMIDES CATALYZED BY AMMONIUM HALIDESalkylation, arylation, dealkylation, dearylation, C‐acylation, olefinationNo abstract is available for this article.doi:10.1002/chin.198031147H.KASHIWAGIS.ENOMOTO
of sustainability, the use of more eco-friendly, inexpensive and widely abundant metals for the synthesis of amines continues to be a long-standing goal of chemical research26. In this respect, it is interesting that Saito reported theN-alkylation of amines based on the combination of iron ...
该反应实用性强:手性配体可以百克级大量合成且无需纯化,可以将复杂药物分子拼接合成孪药等。相关成果以“铜催化烷基胺的立体汇聚式N-烷基化反应(Enantioconvergent Cu-catalyzed N-alkylation of aliphatic amines)”为题,在《自然》(Nature)上...
产品的质量分数可达 99%以上 。 参考文献 [1] Trotta F,Tundo P, Moraglio G .Selective mono-N-alkylation of aromatic amines by dialkyl carbonate under gas-liquid phase transfer catalysis condition [ J] .J Org Chem, 1987,52:1300-1304.
A new effective catalytic system consisting of [Cp*IrCl2]2/K2CO3 (Cp*=pentamethylcyclopentadienyl) for the N-alkylation of primary amines with alcohols has been developed. As an example, the reaction of aniline with benzyl alcohol in the presence of [Cp*IrCl2]2 (5.0 mol%Ir) and K2CO3 ...
The alkylation of amines by alcohols has been achieved using 0.5 mol % [Ru(-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols require more forcing conditions than primary alcohols but are still effective alkylating age...
Chemical methods are commonly used for the N-dealkylation of tertiary amines in natural products allowing re-alkylation and derivatization of the corresponding secondary amines. An important example for this is the N-demethylation of opiate alkaloids using different synthetic methods, a topic that will...
reductive alkylationreductive aminationsecondary amines2‐11C]tert‐butanolThe development of a labeling method for secondary amines with [2- 11 C]acetone is described since the R 2 N -isopropyl moiety is present in many biologically active compounds. The influence of a variety of parameters (e.g...