Secondary amines are vital functional groups in pharmaceuticals, agrochemicals, and natural products, necessitating efficient synthetic methods. Traditional approaches, including-monoalkylation and reductive amination, suffer from limitations such as poor chemoselectivity and complexity. Herein, we present a ...
C. (1994), ChemInform Abstract: Kinetic Studies of the N-Alkylation of Secondary Amines with 1,2- Dichloroethane. ChemInform, 25: no. doi: 10.1002/chin.199422091 Author Information Chem. Eng. Inst., Louvain Univ., B-1348 Louvain-la-Neuve, Belg. Publication History Issue published online: ...
N-chloroacetylglycosylaminespiperazine2-phenylethylaminetryptaminenorephedrineoctopaminedopamineEfficient monoalkylation of a series of primary and secondary amines was demonstrated with the use of N -chloroacetylglycosylamines derived from d -glucose, d -galactose, d -mannose, N -acetyl- d -glucosamine, ...
Amines are very important bulk and fine chemicals, pharmaceuticals, agrochemicals and natural products, and the synthesis of differently substituted secondary alkyl amines is challenging using existing synthesis methodologies. The reaction has a very broad scope and many functional groups, including ...
Ishida T, Kawakita N, Akita T, Haruta M (2009) One-pot N-alkyl- ation of primary amines to secondary amines by gold clusters sup- ported on porous coordination polymers. Gold Bull 42:267-274. doi:10.1007/BF03214948Ishida T, Kawakita N, Akita T, Haruta M (2009) One-pot N-alkylation...
Aminoalkylation of a series of primary and secondary nitriles with N-(alpha-aminoalkyl)benzotriazoles 1 (derived from a variety of secondary amines and ald... Alan R.KatritzkyAshraf A.A.Abdel-FattahPeter J.Steel - 《Tetrahedron Letters the International Journal for the Rapid Publication of Preli...
et al. Enantioconvergent Cu-catalyzed radical C−N coupling of racemic secondary alkyl halides to access α-chiral primary amines. J. Am. Chem. Soc. 143, 15413–15419 (2021). Article CAS PubMed Google Scholar Cho, H. et al. Photoinduced, copper-catalyzed enantioconvergent alkylations of ...
Amine synthesis by reductive amination (reductive alkylation)
Prochiral α‐aminoalkyl radicals generated from RAEs were successfully introduced to N ‐heteroarene derivatives, including pyridine, quinoline, and isoquinoline, resulting in a range of valuable chiral alkylated N ‐heteroarenes with secondary amines in high yields and good to excellent enantio...
ChemInform Abstract: Indirect Monoalkylation of Primary and Secondary Amines by Reductive Decyanation of α-Aminonitriles with Sodium Cyanoborohydride- Mercury Bis(trifluoroacetate)reduction, hydrogenationamines (acyclic compounds)amines (benzene compounds)...