The alkylation reaction kinetics of a series of amines of different structures by dimethyl phosphite have been studied. Two-parameter correlation equations have been deduced, relating reactivity to steric and inductive effects of substituent s attached to the nitrogen atom in the amine; a Swain-Scott...
In organic synthesis, mono -alkylationof amines is an important of reaction. 伯胺的单烷基化在有机合成过程中是非常重要的一类反应. 互联网 Cesium carbonate catalyzed O -alkylationof phenol to synthesize alkly aryl ethers. 摘要研究了碳酸铯催化酚与卤代烃反应制备烷基芳醚. ...
Cycloaddition reaction of the dipolarophiles (II) with munchnones, generated from the N-acyl-α-amino acids (I) by treatment with acetic anhydride, results in predominant or exclusive formation of the pyrroles (IIIa) - (IIId).doi:10.1002/chin.198911109...
providing the corresponding allylic amines in 62−94% yields. In addition, the position of substituents did not have a strong influence on the reaction yield (3b−3dand3h−3j). Notably, both 1-naphthyl (3o) and heteroaryl (3p) instead of the phenyl of1aalso worked well, affording bot...
ALKYLATING agents, such as nitrosamines, nitrosoureas, dimethylsulphate, and so on, are known to cause mutations and cancerous growth1–3. Since nitrosamines can be produced by the reaction of amines and nitrous acid, the presence of nitrites and nitrous acid in many food items as well as in...
Catalytic N-alkylation is a frequently employed method to synthesize secondary amines and imines, yet selectivity control remains as a challenge that normally requires specialized catalysts under harsh reaction conditions. Here we propose a light-switchable N-alkylation of amines with aromatic halides for...
Due to their excellent leaving ability, these TT salts have been found to exhibit high reactivity in halogenation reactions, leading to the formation of isotopically labeled alkyl halides (Fig. 2d). For instance, considering the complex molecule 2o as an example, the reaction readily undergoes ...
In this work, the conversion of alkynes into allylic amines within an unbelievably short reaction time of 4h is presented. In addition to the fast reaction, hydroaminoalkylation is promoted by broad scope, high yields, and excellent stereoselectivity to provide access to synthetically useful products...
Amine synthesis by reductive amination (reductive alkylation)
Unfortunately, most of these materials need drastic reaction conditions (250–500 °C) making them not suitable for the synthesis of more advanced amines, especially life science products such as pharmaceuticals. However, in this field the use of amines is immense, and most of the drugs known ...