alkyl halidesphotocatalysisα-Branched amines represent essential building blocks for organic synthesis. They are traditionally prepared through nucleophilic addition to imines. These methods often require highly reactive organometallic reagents and proceed under rigorous air- and moisture-free conditions. Here ...
2. Although theN-alkylation of aliphatic amines with alkyl halides has been widely adopted for over 100 years, catalyst poisoning and unfettered reactivity have been preventing the development of a
These derivatives are readily obtained byalkylationof 2 - mercaptopyridine and alkyl halides under alkaline conditions. 这些衍生物可以容易地在碱性条件下通过 2- 巯基吡啶和卤代烷的烷基化而得到. 辞典例句 The different contents of variousalkylationproducts were obtained with different catalysts. ...
C. Fu, Transition-metal- catalyzed alkylations of amines with alkyl halides: Photoinduced, copper-catalyzed couplings of carbazoles. Angew. Chem. Int. Ed. 52, 5129-5133 (2013).A. C. Bissember, R. J. Lundgren, S. E. Creutz, J. C. Peters and G. C. Fu, Transition-Metal-Catalyzed ...
et al. Enantioconvergent Cu-catalyzed radical C−N coupling of racemic secondary alkyl halides to access α-chiral primary amines. J. Am. Chem. Soc. 143, 15413–15419 (2021). Article CAS PubMed Google Scholar Cho, H. et al. Photoinduced, copper-catalyzed enantioconvergent alkylations of ...
amines Inamine: Occurrence and sources of amines …are typically made by direct alkylation of secondary amines by alkyl halides: Read More arenes Inhydrocarbon: Reactions include nitration, halogenation, sulfonation, alkylation, and acylation.
et al. Enantioconvergent Cu-catalyzed radical C−N coupling of racemic secondary alkyl halides to access α-chiral primary amines. J. Am. Chem. Soc. 143, 15413–15419 (2021). Article CAS PubMed Google Scholar Cho, H. et al. Photoinduced, copper-catalyzed enantioconvergent alkylations of ...
Hydrogen borrowing is an attractive and sustainable strategy for carbon–carbon bond formation that enables alcohols to be used as alkylating reagents in place of alkyl halides. However, despite intensive efforts, limited functional group tolerance is observed in this methodology, which we hypothesize is...
ChemInform Abstract: Indium—Silver‐ and Zinc—Silver‐Mediated Barbier—Grignard‐Type Alkylation Reactions of Imines by Using Unactivated Alkyl Halides in Aqueous Media.amines (benzene compounds)amines (acyclic compounds)multicomponent reactionsamino acids, peptides...
STEP 1: Formation of the electrophile [CH3+] STEP 2: The electrophile attacks the benzene ring to give a carbonium ion. STEP 3: Loss of proton gives alkylbenzene. Limitations of Friedel craft alkylation: The halide must be an alkyl halide. Vinyl or aryl halides do not react. ...