The immune system, which is essential for tumor control and elimination, comprises lymphocytes, NK cells, antigen-presenting cells (APCs), and B cells. In hosts with tumors, MDSCs play a critical role in promoting tumor immune escape by inhibiting the immune cells responsible for tumor destructio...
et al. Anti-PD-L1 efficacy can be enhanced by inhibition of myeloid-derived suppressor cells with a selective inhibitor of PI3Kδ/γ. Cancer Res. 77, 2607–2619 (2017).This paper describes the therapeutic effect in mice after downregulation of MDSCs with PI3K inhibitor. Article CAS PubMed ...
This article reviews the characterization and suppressive mechanisms used by MDSC to block tumor immunity and describes the mechanisms by which inflammation promotes tumor progression through the induction of MDSC. 展开 关键词: T-Lymphocytes Myeloid Cells Animals Humans Neoplasms Inflammation S100 Proteins...
et al. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci. Immunol. 1, aaf8943 (2016). This study describes, for the first time, that gene expression profiles of PMN-MDSCs and neutrophils from the same...
This review describes the expression and regulation of the MPO gene in myeloid cells including myeloid disorders, such as myeloid leukemia or myelodysplastic syndromes, The effects on MPO by myeloid growth factors and signal transduction from their receptors are also presented.doi:10.3109/...
Condamine, T. et al. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.Sci. Immunol.1, aaf8943 (2016).This study describes, for the first time, that gene expression profiles of PMN-MDSCs and neutrophils from...
(which involves relatively low-intensity signals) causes sustained myelopoiesis. Although the exact nature of these myeloid cells depends on the pathogenic stimulus in the host, they share several similar features: lack or reduced expression of mature myeloid cell markers, inability to differentiate ...
Background The theory of cancer immunoediting, which describes the dynamic interactions between tumors and host immune cells that shape the character of each compartment, is foundational for understanding cancer immunotherapy. Few models exist that facilitate in-depth study of each of the three canonical...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in he...
This review describes recent findings on the role of myeloid cells in refractoriness or/and acquired resistance to such therapies.Various myeloid cell types, including tumor-associated macrophages, Tie2-expressing monocytes and neutrophils, have been implicated in tumor angiogenesis. Several cytokines ...