et al. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci. Immunol. 1, aaf8943 (2016). This study describes, for the first time, that gene expression profiles of PMN-MDSCs and neutrophils from the same...
et al. Anti-PD-L1 efficacy can be enhanced by inhibition of myeloid-derived suppressor cells with a selective inhibitor of PI3Kδ/γ. Cancer Res. 77, 2607–2619 (2017).This paper describes the therapeutic effect in mice after downregulation of MDSCs with PI3K inhibitor. Article CAS PubMed ...
The population of myeloid cells is highly diverse. Myeloid cells include mononuclear phagocytes (MNPs) (encompassing macrophages, monocytes, and dendritic cells [DCs]) and granulocytes (mast cells, neutrophils, eosinophils, and basophils), which play a variety of different and specific roles in prote...
This article reviews the characterization and suppressive mechanisms used by MDSC to block tumor immunity and describes the mechanisms by which inflammation promotes tumor progression through the induction of MDSC. 展开 关键词: T-Lymphocytes Myeloid Cells Animals Humans Neoplasms Inflammation S100 Proteins...
Condamine, T. et al. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.Sci. Immunol.1, aaf8943 (2016).This study describes, for the first time, that gene expression profiles of PMN-MDSCs and neutrophils from...
Terabe, M. et al. Transforming growth factor-β production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.J. Exp. Med.198, 1741–1752 (2003). ...
is the published study 鈥 entitled "RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression" 鈥 which describes how RepSox, a "small molecule" reprogramming tool and TGF-尾 inhibitor, affects AML cells. The key findings are RepSox (1)...
Because MDSCs are present in most cancer patients and are potent immune-suppressive cells, MDSCs have been the focus of intense research in recent years. This review describes the history and identification of MDSCs, the role of inflammation and intracellular signaling events governing MDSC ...
This chapter describes the myeloid cells of the peripheral blood: neutrophils, eosinophils, basophils, and monocytes. It describes their basic physiology and important disease states associated with defects of each of these entities. Each of these cells arise from a common bone marrow myeloid progenito...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in he...