During hematopoiesis in humans, cells of the myeloid lineage are derived from a common myeloid progenitor (CMP) in the bone marrow. This lineage—which includes monocytes, granulocytes, erythrocytes, and platelets—is a primary component of the innate immune system and serves as a first line of...
Myeloid cells are the most abundant immune components of the tumour microenvironment, where they have a variety of functions, ranging from immunosuppressive to immunostimulatory roles. The myeloid cell compartment comprises many different cell types, including monocytes, macrophages, dendritic cells and gran...
Myeloid cells are the most abundant immune components of the tumour microenvironment, where they have a variety of functions, ranging from immunosuppressive to immunostimulatory roles. The myeloid cell compartment comprises many different cell types, including monocytes, macrophages, dendritic cells and ...
Myeloid cells are a type of daughter cells produced by hematopoietic stem cells. Myeloid cells are progenitor cells of different types of cells. They produce many different types of blood cells includingmonocytes, macrophages,neutrophils,basophils, eosinophils, erythrocytes, dendritic cells, megakaryocytes...
Bona fide MDSCs do not really exist in healthy individuals; although there are precursors of mature myeloid cells that share the same phenotype, they do not have the same functions. Instead, MDSCs accumulate during the pathological response to long-term unresolved chronic infection, inflammation, ...
1.1.1Myeloid cells Myeloidcells are comprised ofmonocytes, dendritic cells (DCs), tissue macrophages and granulocytes. Myeloid cells bridge innate andadaptive immunity, mainly through antigen processing and presentation and recruitment of adaptiveimmune cells. The development and function of circulating mye...
Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Here we show single-cell transcriptomics and fun
Myeloid cells are components of the innate immune system that represent the first line of defense. Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the extracellular environment. Myeloid cells detect ...
However, the amount of HLA-G transcripts and the expression of the protein are not related. HLA-G expression or secretion by DC may have negative consequences on the function of effective immune cells and also on DC themselves via the interaction with inhibitory receptors expressed by these ...
Myeloid cells (granulocytes and monocytes/macrophages) play an important role in neuroblastoma. By inducing a complex immunosuppressive network, myeloid cells pose a challenge for the adaptive immune system to eliminate tumor cells, especially in high-ri