During hematopoiesis in humans, cells of the myeloid lineage are derived from a common myeloid progenitor (CMP) in the bone marrow. This lineage—which includes monocytes, granulocytes, erythrocytes, and platelets—is a primary component of the innate immune system and serves as a first line of...
Myeloid cellsareimmune cellsderived from the common myeloid progenitor, and they are hypothesized to play a unique role in the development and progression ofpediatricCNS tumors. Given that myeloid cells are one of the brain's primary immune mechanisms, gaining a better understanding of how myeloid ...
There are two clearly identified subpopulations: Mononuclear-type myeloid-derived suppressor cells (M-MDSCs) and polymorphonuclear (PMN-MDSCs). These cell population subtypes play a very important role, depending on the type of cancer, since they have the particularity of expressin...
Myeloid cells are a type of daughter cells produced by hematopoietic stem cells. Myeloid cells are progenitor cells of different types of cells. They produce many different types of blood cells includingmonocytes, macrophages,neutrophils,basophils, eosinophils, erythrocytes, dendritic cells, megakaryocytes...
Myeloid cellsareimmune cellsderived from the commonmyeloidprogenitor, and they are hypothesized to play a unique role in the development and progression ofpediatricCNS tumors. Given thatmyeloid cellsare one of the brain's primary immune mechanisms, gaining a better understanding of how myeloid cells ...
Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Here we show single-cell transcriptomics and fun
Staining cells with special dyes (called immunohistochemistry) that can show what kind of cells they are. These tests are called immunophenotyping tests, and they use a special machine called a flow cytometer to help sort the cells into their different types. These tests tell your doctor what ty...
What is acute myeloid leukemia?Acute myeloid leukemia (AML) is also called acute myelogenous leukemia. It is a fast-growing cancer of the bone marrow and blood cells. Cells that should become white blood cells (WBCs) do not fully grow. These cells are called myeloblasts and monoblasts. ...
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors mark...
Myeloid cells (granulocytes and monocytes/macrophages) play an important role in neuroblastoma. By inducing a complex immunosuppressive network, myeloid cells pose a challenge for the adaptive immune system to eliminate tumor cells, especially in high-ri