( 2007 ) Myeloid-derived suppressor cells . In: Immune-Mediated Diseases (eds by M.R. Shurin & Y.S. Smolkin ), pp. 213 – 223 . Springer, New York.Finn OJ. Cancer immunology. N Engl J Med 2008 ; 358:2704-15; PMID: 18565863 ; http://dx.doi.org/ 10.1056/NEJMra072739...
et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111, 4233–4244 (2008). Article CAS PubMed Google Scholar Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune...
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However...
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However...
Myeloid-derived suppressor cells Myeloid-derived suppressor cells(MDSCs) are a heterogenous population of suppressive immaturemyeloid cellsthat develop in the bone marrow (BM) and are recruited to sites of infection orinjuryto control inflammation[23]. However, in the context ofsolid tumors, the...
The initiation and progression of tumors depend on the metabolic reprogramming of cancer cells to fulfill their bioenergetic and biosynthetic demands to support rapid proliferation as well as constitute immune suppressive tumor microenvironment (TME) [6]. Not only tumor cell-derived cytokines, but also...
MDSCs are discriminated from other myeloid cell types in which they possess strong im-munosuppressive activities rather than immunostimula-tory properties.Similar to other myeloid cells,MDSCs interact with other immune cell types including T cells, dendritic cells,macrophages and natural killer cells ...
Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor Several immune suppressive mechanisms that evade the host immune response have been described in patients with hepatocellular carcinoma (HCC); one of these... B Hoechst,T Voigt...
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated with poor clinical outcomes in cancer. Recent studies hav...
Myeloid-derived suppressor cells (MDSCs) are proposed to control graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the definition of human MDSCs has not yet reached consensus, and the mechanism of MDSCs to control GVHD remains unclear. ...