Kotschy et al., Nature 2016 Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival...
Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic member of the Bcl-2 protein family. It interacts with proapoptotic Bcl-2 family members, thereby inhibiting mitochondrial activation and induction of apoptosis. Mcl-1 is essential for embryonal development and the maintenance of B cells, T c...
Myeloid cell leukemia 1protein kinase signalingSRC family kinasesMyeloid cell leukemia-1 (MCL-1), closely related to B-cell lymphoma 2 (BCL-2), has a well-established role in cell survival and has emerged as an important target for cancer therapeutics. We have demonstrated that inhibiting MCL...
1 activates the expression of antiapoptotic target genes to protect Leydig cells from apoptosis. In silico analysis of testis genes containing a consensus hypoxia response element (HRE, 5'-RCGTG-3') identified myeloid cell leukemia-1 (Mcl-1) as a potential HIF-1 target gene. The purpose ...
Cancer stem cellChemotherapy resistanceApoptosisBackground Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic protein that regulates apoptosis sensitivity in a variety of cell types. Here we evaluate the roles of Mcl-1 in chemotherapy-associated apoptosis in gastric cancer cells. In addition, our ...
网络髓细胞白血病基因-1 网络释义 1. 髓细胞白血病基因-1 混合细胞系白血病基... ... )Myeloid cell leukemia-1髓细胞白血病基因-1) mixed lineage leukemia gene 混合细胞系白血病基因 ... www.dictall.com|基于 1 个网页 例句
英文名称:Myeloid Cell Leukemia Sequence 1 (MCL1) Antibody,中文名称:粒细胞白血病序列1(MCL1)抗体,产品货号:Catalogue No: abx009004,MCL1抗体是一种抗MCL1的兔多克隆抗体。目标MCL1反应性人、狗、猪宿主兔克隆性多克隆试验应用程序W
Mcl-1: myeloid cell leukemia-2 TNBC: triple-negative breast cancer ER: estrogen receptor PR: progesterone receptor HER2: human epidermal growth factor receptor-2 Bcl-2: B-cell CLL/lymphoma 2 Bcl-xL: Bcl-2-like protein 1 isoform 1 BH3: Bcl-2 homology domain 3 siRNA: small-...
Myeloid cell leukemia 1 (Mcl-1) is a key regulator of the intrinsic apoptosis pathway. Overexpression of Mcl-1 is correlated with high tumor grade, poor survival, and both intrinsic and acquired resistance to cancer therapies. Herein, we disclose the structure-guided design of a small molecule...
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