Inayama S, Okano H, Takamatsu K, Mikoshiba K, Tsukuda Y, Watanabe I (1985) Molecular genetic analysis of myelin deficient mice: Shiverer mutant mice show deletion in gene(s) coding for myelin basic protein (MBP). J
Citrullinated or unmodified myelin was injected into the primary motor cortex above the cingulum bundle at the time of reversion to normal chow and the consequent impact on remyelination was assessed by measuring the surface area of myelin basic protein-positive fibers in the cortex 3weeks later. ...
Proteolipid protein and myelin basic protein), and accordingly there are shared transcriptional pathways. For example, Sox10 is required throughout Schwann cell and oligodendrocyte development, and its expression is also maintained in mature myelinating cells, (Bremer et al., 2011; Stolt et al., ...
Alternatively, the lumbosacral spinal cord was retrieved unfixed, sectioned sagittally and snap frozen for either protein or RNA isolation (n = 10 mice per group). All animal experiments were carried out with adherence to NIH Guidelines for animal care and safety and were approved by the Mayo ...
1 46 . Panitch H , Ciccone C , Induction o f recurrent experimental allergic encephalomyelitis with myelin basic protein. Ann Neurol 1 98 1 ;9:433-8 . 1 47 . Raine C S , Traugott U, Farooq M, B ornstein M B , Norton WT. Augmentation of immune- mediated demyelination by lipid ...
Some patients had only leptomeningeal enhancement, and only a few or no cortical hyperintensities, described in a review from Mayo Clinic and referred to as FLAIR-variable Unilateral Enhancement of the Leptomeninges (FUEL) [51]. Patients with FLAMES predominantly present with focal onset seizures, ...
Aging is a natural phenomenon that involves many biological changes, including increased oxidative stress, DNA damage and diminished protein regulation, mitochondrial dysfunction, impaired immune responses, and vascular abnormalities [1]. Most of the aforementioned changes associated with aging are also vali...
Mice consuming high fat with coordinate voluntary running wheel exercise for 7 weeks showed increases in the abundance of the major myelin membrane proteins, proteolipid (PLP) and myelin basic protein (MBP), in the lumbosacral spinal cord. Expression of MBP and PLP RNA, as well that for Myrf...