(2003). Structural genomics of Mycobacterium tuberculosis: a prelimi- nary report of progress at UCLA. Biophys. Chem. 105, 361-370.Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophys Chem 105 - Goulding, Perry, et al. - 2003 () Citation ...
This strain has been the source of several tuberculosis outbreaks over the last 30 years and anecdotal evidence suggests it may be particularly virulent. Two other large clusters, known as the 鈥楽outhern Cross鈥and 鈥極tara鈥clusters, most commonly occur in Pacific People.Here, whole genome ...
In Mycobacterium tuberculosis, Rv3806c is a membrane-bound phosphoribosyltransferase (PRTase) involved in cell wall precursor production. It catalyses pentosyl phosphate transfer from phosphoribosyl pyrophosphate to decaprenyl phosphate, to generate 5-phospho-β-ribosyl-1-phosphoryldecaprenol. Despite Rv38...
The aim of the present study was to describe structural and phylogenetic features ofM. tuberculosisTlyA, using bioinformatics tools. The structural and phylogenetic analysis shown here highlights the need for re-annotating this protein family and redefining it as an RNA-binding FtsJ-like methyltransfer...
Bacterial D is ulfide b ond forming (Dsb) proteins facilitate proper folding and disulfide bond formation of periplasmic and secreted proteins. Previously, we have shown that Mycobacterium tuberculosis Mt-DsbE and Mt-DsbF aid in vitro oxidative folding o
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an infectious disease that is responsible for major health and economic costs worldwide1. Mtb encounters diverse environments during its life cycle and responds to th
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. (cover story) Presents research which completed the genome sequence for the Mycobacterium tuberculosis strain H37Rv. Number of base pairs and genes; Very high guanine an... Cole,T S.,Brosch,... - 《Nature》 ...
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu could be an excellent target for treating Mtb infection. Here, we report the cryst
Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by py...
The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other M. tuberculosis researchers to identify M. tuberculo...