Tuberculosis is caused by Mycobacterium tuberculosis . The word tuberculosis is derived from the word tubercle, meaning a small lump or nodule ( Wolinsky 1988 ). The disease was first described by Jean-Antoine Villemin, a French military doctor in 1868, when he successfully transmitted the ...
Drug-induced differential culturability in diverse strains ofMycobacterium tuberculosis Valerie F. A. March ,Nino Maghradze &Sonia Borrell Article 28 January 2025|Open Access Discovery of two novelFlavobacteriumspecies with potential for complex polysaccharide degradation ...
Mycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have distinct abilities to restrict Mtb. What enables Mtb survival in certain macrophage populations is not well understood. Here we used transposon sequencing analysis of Mtb in wild-type and autophagy-deficient mouse ma...
2024年3月29日,Cell Discovery(IF:33.5)杂志发表由戈宝学教授领衔,联合结核病实验室王琳研究员和同济大学生命与科学技术学院高亚威研究员共同通讯完成的研究工作“Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA...
2024年3月15日，上海科技大学免疫化学研究所张璐研究员/饶子和院士团队在国际微生物领域权威期刊Nature Microbiology在线发表了题为“Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis inMycobacterium tuberculosis”的研究论文，率先报道了结核分枝杆菌全新药物靶标——膜蛋白磷酸核糖转移酶...
2024年3月15日,上海科技大学免疫化学研究所张璐研究员/饶子和院士团队在国际微生物领域权威期刊Nature Microbiology在线发表了题为“Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis inMycobacterium tuberculosis”的研...
Tuberculosis(TB) is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usuallyMycobacterium tuberculosis. Tuberculosis may infect any part of the body, but most commonly occurs in the lungs. Globally, tuberculosis is thesecond most commoncause of death...
In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but the mechanisms involved in PLC-induced cell death are not fully understood. It has been reported that induction of cell necrosis by virulent Mtb is coordinated by subversion of PGE2, an essential factor in cell ...
Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique Background Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genoty... SO Viegas,A Machado,R Groenhe...
The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic diversity of this loc...