Tuberculosis is a significant global health threat, with one-third of the world’s population infected with its causative agent Mycobacterium tuberculosis (Mtb). The emergence of multidrug-resistant (MDR) Mtb that is resistant to the frontline anti-tubercular drugs rifampicin and isoniazid forces trea...
[2]Departments of Medicine, Critical Care Medicine, Pathology and Laboratory Medicine, and Community Health Sciences, University of Calgary, Calgary, Alberta; [3]Department of Microbiology-Infectious Diseases, Université de Sherbrooke, Sherbrooke, Quebec Author notes Correspondence: Dr Kevin B Laupland,...
The intracellular pathogen Mycobacterium tuberculosis (Mtb) can survive in the host and cause disease by interfering with a variety of cellular functions. The mammalian cell entry 2 (mce2) operon of Mtb has been shown to contribute to tuberculosis pathog
Value analysis of next-generation sequencing combined with Xpert in early precise diagnosis of pulmonary tuberculosis 2023, Diagnostic Microbiology and Infectious Disease Citation Excerpt : With the development of molecular biotechnology, rapid, and specific techniques with high sensitivity have also entered ...
Dendritic cells (DCs) connect innate and adaptive immunity, and are necessary for an efficient CD4+ and CD8+ T cell response after infection with Mycobacterium tuberculosis (Mtb). We previously described the macrophage cell death response to Mtb infectio
“TB notes” of TB cases andM. tuberculosiscultures isolated in the greater Vitória region. This search identified 72 cases of TB in the HHCs. Seven of the HHC were found to have had a case of TB that predated the onset of TB in the “index case” that had led to the HHC ...
There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and regimens vary in treatment-shortening activity, but the molecular basis of these differences is unclear, and no existing assay directly quantifies the ability of a drug or regimen to shor...
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a major health threat listed among the top 10 causes of death worldwide. Treatment of multidrug-resistant Mtb requires use of additional second-line drugs that prolong the treatment process and
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. We found that by inducing the microRNA (miRNA) miR-33 and its passenger strand miR-33*, Mtb inhibited integ...
Genetic characterization of Mycobacterium tuberculosis in the West Bank, Palestinian Territories BMC Res Notes, 5 (2012), p. 270 View in ScopusGoogle Scholar 54. Jagielski T, Ignatowska H, Bakula Z, Dziewit L, Napiórkowska A, Augustynowicz-Kopec E, et al. Screening for streptomycin resist...