数字 4显示了为 MYC_TARGETS_V1 基因组的 294 名患者队列中抽取的N = 200的一个子集生成的零分布 ,该基因集用于没有分裂 (ES)、一个分裂 (ES avg )、两个分裂和 25 个分裂的子集的测试统计. 随着平均分裂数增加到 1 以上,分布失去其多峰结构但保持相同的总宽度。 图4 ES 和 <ES avg > 的空分布。
We found that high MYC scores were associated with worse survival in metastatic breast cancer. Our findings show that the MYC targets v1 and v2 scores are associated with tumor aggressiveness and poor prognosis in ER-positive primary tumors, as well as in metastatic breast cancer. 展开 ...
Additionally, we observed elevated expression of MYC Targets V1 genes in the basal, intermediate, and cancer clusters compared to benign luminal epithelial clusters (Supplementary Fig. 7A–F). Validation studies with in situ tissue staining confirmed the over-expression of nuclear MYC in prostate can...
The set MYC_TARGETS_v1 is significantly repressed by MYC depletion. siMYC: MYC specific siRNA, siCTR: negative control siRNA. To gain insight into the transcriptional effect of JQ1, LS174t cells were incubated with 500 nM JQ1 for 48 h and total RNA were compared with LS174t cells ...
Here we show that ELL functions as an E3 ubiquitin ligase and targets c-Myc for proteasomal degradation. In addition, we identify that UbcH8 serves as a ubiquitin-conjugating enzyme in this pathway. Cysteine 595 of ELL is an active site of the enzyme; its mutation to alanine (C595A) ...
Macrophages as tools and targets in cancer therapy [J]. Nat Rev Drug Discov. 2022;21(11):799–820. Article CAS PubMed PubMed Central Google Scholar Klichinsky M, Ruella M, Shestova O, et al. Human chimeric antigen receptor macrophages for cancer immunotherapy [J]. Nat Biotechnol. 2020...
Based on this finding, exploring new therapeutic targets and clarifying their mechanism of activation may solve the problem of TKI resistance in Ph+ B-ALL. Interestingly, Sup-B15 was not only the primary resistant cell line of imatinib caused by BCR-ABL1-independent AKT phosphorylation [34] but...
TARGETSMCM2-7 HELICASEEXCESS MCM2-7GINS COMPLEXHUMAN-CELLSc-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when deregulated. Previous studies have demonstrated a nontranscriptional role for c-Myc in ...
is required for NSCLC progression.208Crucial genes in mitochondrial replication and biogenesis, such as DNA polymerases and the nuclear respiratory factor 1 (NRF-1), are direct targets of MYC.209Finally, the interaction between MYC and the host cell factor 1 (HCF1) has also been recently linked...
Common fragile sites as targets for chromosome rearrangements. DNA Rep 2006; 5: 1126–1135. 24 Ferber MJ, Eilers P, Schuuring E, Fenton JA, Fleuren GJ, Kenter G et al. Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus ...