发现以下信号通路存在差异:COMPLEMENT、MYC_TARGETS_V1、MYC_TARGETS_V2。表明MYC靶向基因可能是肿瘤休眠机制的关键。 作者又将休眠细胞中显著下调的基因与MYC_TARGETS_V1和MYC_TARGETS_V2中的基因取交集,得到3个与MYC相关的显著下调基因Ccna2、Mad2L1和Plk1。
A. Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Rimpi, S.; Nilsson, J. A. Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Biochemical Society transactions 2007, 35, 305-10. [15]...
MA5-12080 targets c-myc in FACS, IF, IHC (P), IM, IP, and WB applications.The MA5-12080 immunogen is a synthetic peptide, aa 408-439, (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc. 靶标信息 The c-Myc protein is a 62 kDa transcription factor that is ...
individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse ta...
其中一些具有十分重要的生物学意义,如:编码细胞周期蛋白及细胞周期蛋白依赖性激酶(CDKs)的基因[7];下调磷酸酶-张力蛋白(PTEN)基因,从而导致PI3K/AKT/mTOR信号通路的上调[8];绕过bcl-2凋亡程序,稳定编码促凋亡蛋白的抑癌基因p53[9];另一些转录靶点(transcriptional targets)包括抑制肿瘤及致瘤的miRNA[10]。有研究...
chemotherapy.Theyexpected targets treatmentofNB. 4The and and andsox2in correlationsbetween oct4,oct4 c-Mycsox2,c-Myc childrenNBtissueswereall thatthethree correlated,whichsuggested positively factorshad effectinthe and ofNB.The progression synergistic development correlationsbetweenand ...
(37.05±1.55)%,(32.49±1.36)%.与对照组比较,苯扎贝特和非诺贝特的中,高浓度组 G1期细胞比率均明显增 加,苯扎贝特和非诺贝特的低,中,高浓度组的细胞凋亡率均明显增加,c-myc mRNA 和蛋白相对表达量均明显降低,差异具有统 计学意义(P<0.05).结论:苯扎贝特和非诺贝特可抑制 PC-9 细胞增殖,并下调 c-myc...
Transcriptional Profiles of Intestinal Tumors in ApcMin Mice are Unique from those of Embryonic Intestine and Identify Novel Gene Targets Dysregulated in H... The adenomatous polyposis coli (APC) tumor suppressor is a major regulator of the Wnt signaling pathway in normal intestinal epithelium. APC,...
1.为确定dMyc在果蝇Imd免疫通路中的功能,利用Gal80 ts -tub-Gal4系统 构建多种dMyc突变果蝇品系:dMyc高表达果蝇品系、dMyc敲低型果蝇品系以 及dMyc和dMyc-RNAi共高表达果蝇品系。在感染大肠杆菌E.coli后,分别检 测果蝇Imd通路下游标志性抗菌肽Diptericin的表达。实验结果表明高表达dMyc ...