A. Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Rimpi, S.; Nilsson, J. A. Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Biochemical Society transactions 2007, 35, 305-10. [15]...
Simpkins F, Jang K, Yoon H, Hew KE, Kim M, Azzam DJ, Sun J, Zhao D, Ince TA, Liu W, et al. 2018. Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells.Clin Cancer Res24: 4874–4886.doi:10.1158/1078-0432.CCR-17-3697 Spreafico ...
MA5-12080 targets c-myc in FACS, IF, IHC (P), IM, IP, and WB applications.The MA5-12080 immunogen is a synthetic peptide, aa 408-439, (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc. 靶标信息 The c-Myc protein is a 62 kDa transcription factor that is ...
其中一些具有十分重要的生物学意义,如:编码细胞周期蛋白及细胞周期蛋白依赖性激酶(CDKs)的基因[7];下调磷酸酶-张力蛋白(PTEN)基因,从而导致PI3K/AKT/mTOR信号通路的上调[8];绕过bcl-2凋亡程序,稳定编码促凋亡蛋白的抑癌基因p53[9];另一些转录靶点(transcriptional targets)包括抑制肿瘤及致瘤的miRNA[10]。有研究...
chemotherapy.Theyexpected targets treatmentofNB. 4The and and andsox2in correlationsbetween oct4,oct4 c-Mycsox2,c-Myc childrenNBtissueswereall thatthethree correlated,whichsuggested positively factorshad effectinthe and ofNB.The progression synergistic development correlationsbetweenand ...
individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse ta...
1.为确定dMyc在果蝇Imd免疫通路中的功能,利用Gal80 ts -tub-Gal4系统 构建多种dMyc突变果蝇品系:dMyc高表达果蝇品系、dMyc敲低型果蝇品系以 及dMyc和dMyc-RNAi共高表达果蝇品系。在感染大肠杆菌E.coli后,分别检 测果蝇Imd通路下游标志性抗菌肽Diptericin的表达。实验结果表明高表达dMyc ...
permeabilized with 0.1% Triton™ X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Myc Tag Monoclonal Antibody (Product #MA5-12080) at 1:100 dilution and Histone H3 antibody (Product #711055) at 1:200 dilution in 0.1% BSA, incu...
The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. 靶标信息 The c-Myc protein ...
The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. 靶标信息 The c-Myc protein is a 62 kDa ...