Further experiments showed that LentiMutate was able to identify mutations that conferred resistance to the fourth-generation anti-EGFR drug osimertinib, which is now the standard of care for EGFR mutant non-small cell lung cancer. The approach also identified mutations that cause resistance to imatin...
DNA mutations (变异) cause cancer cells to grow out of control, but they also produce the variety that enables organisms (有机体) to adapt to their environments and grow. Until now, biologists have only had immature methods for calculating the average rates and effects of mutations. But in ...
Meanwhile, the rise of resistance has resulted in a shift in thinking about cancer treatment. “There’s this school of thought that maybe we shouldn’t be thinking about curing cancer, maybe we should be thinking about managing the disease and giving patients the best quality of life, in th...
unpredictable DNA copying "mistakes" account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world.
The review analyzes the mutations that lead to cell malignant transformation and describes the contribution that self-renewal of adult tissues makes to tumorigenesis. Cancer progression is considered as a development of a complicated system where cells mutate, evolve, and are subject to selection. ...
MELBOURNE, June 21 (Xinhua) -- A study published on Wednesday has brought Australian researchers a step closer to understanding gene mutations that can cause breast cancer. Scientists from the University of Melbourne and Peter MacCallum Cancer Centre have for the first time accurately established the...
Smoking cannabis can alter a person’s DNA, causing mutations that can cause serious illnesses including cancer, according to a disturbing new peer-reviewed study. Perhaps even more surprisingly, the heightened risk is not exclusive to person smoking cannabis. The disease-causing mutations are passed...
While mutations do contribute to the development of cancer, not all mutations cause cancer. Most cancer cells have several mutations that work together to cause cell division to proceed at inappropriate times. For example, there may b...
In this work, the most detrimental missense mutations of p110α that cause various types of cancer were identified computationally and the binding efficiencies of those missense mutations with regulatory subunit p85 were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs...
Paclitaxel Resistance in Non–Small-Cell Lung Cancer Associated With Beta-Tubulin Gene Mutations The mechanisms that cause chemoresistance in non-small-cell lung cancer (NSCLC) patients have yet to be clearly elucidated. Paclitaxel is a tubulin-disrupt......