Results from a comprehensive evaluation of the function ofBRCA2variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of individuals who carry such genetic variants. Huaizhi Huang
Andrew Futreal1 All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving...
Although it is recognized that cancer is a complex disease affected by many factors, the most widely accepted genetic theory is that tumorigenesis results from somatic mutation accumulation, i.e., tumors are formed by the accumulation of somatic mutations through evolutionary processes [27, 61]. Th...
In this review article, we will provide an overview of the current state of the field of CRISPR-based gene editing in cancer therapy, highlighting the most promising results and the challenges that still need to be overcome. We will describe the different CRISPR-based strategies that have been ...
For example, in hereditary cancers such as breast cancer, genomic instability, which drives these cancers, is known to result from mutations in DNA repair genes such as BRCA 1/2 (Bartkova et al., 2005). Defects in DDR mechanisms are generally known as major drivers of development in most ...
The results showed that the high correlations they found in 2015 between cancer incidence and cell divisions are universal rather than confined to the United States. For example, that 77 percent of mutations in pancreatic cancers are due to random DNA copying errors, 18 percent to environmental ...
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with drugs is challenging because KRAS is considered undruggable due to the lack of classic drug bi
Patients were stratified by high (> = 2) and low (< 2) mutations from the 141 mutations that are present in both the MSK-Impact dataset and panel (I). scRNA-seq Analysis Reveals a Rich Complexity of Expressed Gene Alterations in Cancer Cells Additional genetic alterations can co-exist ...
Symptom monitoring with electronic patient-reported outcomes during cancer treatment: final results of the PRO-TECT cluster-randomized trial A cluster-randomized controlled trial found that using an electronic system for symptom monitoring of patient-reported outcomes during treatment led to sustained improve...
Impact of population screening for Lynch syndrome insights from the All of Us data Lynch Syndrome results in a predisposition to cancer, however, it is frequently undiagnosed prior to cancer occurrence. Here, the authors use All of Us data to report that 63.2% of Lynch syndrome carriers remain...