Since 1996, the highly pathogenic avian influenza (HPAI) virus (H5N1) has caused more than 1000 deaths, resulting in a mortality rate of about 55% [9]. Recently, a low-pathogenic avian influenza (LPAI) virus (H7N9) identified first in the East China region caused an outbreak in humans,...
The mutation rate of a virus has been described as the probability that during a single replication of the virus genome a particular nucleotide position is altered. From:Genetics and Evolution of Infectious Disease,2011 About this page Set alert ...
A high mutation rate was initially beneficial bec... Giraud,A - 《Science》 被引量: 946发表: 2001年 Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. The rates of mutation to the mar (monoclonal antibody-resistant) genotype of individual influenza virus ...
Influenza A virus infection and pregnancy in mice: reduced ability of leukocyte homing to the lung and high virus mutation rate account for enhanced gestational morbidity and mortalityRecurrent pregnancy lossMiscarriageaCGHBackground: Determination of fetal aneuploidy is central to evaluation of recurrent ...
To assess our criteria for separating positive and negative samples, we used the same threshold calculations with a random subset of negative samples (50%, N = 35) resulted in a false positive rate of 0.03 and a false negative rate of zero (N = 100 trials). A small proportion ...
However, the growth of AIVs in Vero cells is generally slower than in MDCK cells or eggs25, and improving the slow growth rate of AIV vaccine viruses in Vero cells is highly desirable26. Here, we report the identification of a growth-enhancing mutation in the N-terminal region of the ...
The mutation rate of an organism is defined as the probability that a change in genetic information is passed to the next generation. In viruses, a generation is often defined as a cell infection cycle, which includes attachment to the cell surface, entry, gene expression, replication, encapsida...
4.Second, the virus mutates at an extraordinary high rate, generating billions of new variants each day(1).第二,病毒变异性高,每天产生数以十亿计的变体。 5.Pathogenicity Differentiation and Molecular Variation of Rice Stripe Virus水稻条纹病毒致病性分化与分子变异 ...
27. It is possible that higher levels of functional S protein observed with PVG614increase the chance of host-to-host transmission, but other factors limit the rate and efficiency of intra-host replication. Alternatively, the loss of virion-associated S proteins observed with SD614may be ...
For example, in India we found a major mutation at the P681 position but with an R (9.71%) instead of the H mutation. The R mutation is also found in the Delta variant (B.167.2). This variant is of considerable public concern, as it is increasing with a high rate in many ...