Gluteal Muscle Fatty Atrophy: An Independent Risk Factor for Surgical Treatment in Elderly Patients Diagnosed with Type-III Fragility Fractures of the Pelvis 2023, Journal of Clinical Medicine Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy 2020, Neurology1...
Mammalian animal models for Duchenne muscular dystrophy Raffaella Willmann, ... Markus A. Ruegg, in Neuromuscular Disorders, 2009 3.3 mdx52 To create a mouse model with large deletions in the dystrophin gene like those found in two thirds of human patients, exon 52 was disrupted on a C57BL...
This family shows the clinical variability of myotonic muscular dystrophy. In this family the histological picture with atrophy of type I muscle fibers was im porta nt for the genetic diagnosis of this unusual phenotype. Schara, URuhr Univ BochumHoffmann, UVorgerd, MMortier, Wmonatsschrift kinder...
Previous work has shown that mutations in the integrin α7 (ITGA7)were a cause of congenital muscular dystrophy with a disease phenotype not entirely distinct to DMD6,144. Here, Mayer144showed that the absence of α7 caused necrosis of myofibres, centralised nuclei, and disrupted sarcomeric ar...
the muscle weakness can indicate serious problems related to your brain, spinal cord, neurological diseases, dermatomyositis, muscular dystrophy, metabolic disorders (Addison’s disease), amyotrophic lateral sclerosis, pinched nerve, myasthenia gravis, Charcot-Marie-Tooth disease, double vision, botulism, ...
maintenance of redox homeostasis. Skeletal muscle dystrophy manifests itself with cardiac dysfunction abnormal gait, muscular atrophy with associated muscle weakness. The severity of the symptoms can extend into diagnostic regimes like defects in joint movement and contractures, muscle pain and wasting50....
Muscular dystrophy Polymyositis Dermatomyositis Inclusion body myositis Neurogenic atrophy Trichinosis Amyotrophic lateral sclerosis (ALS) Your doctor will most likely ask for a muscle biopsy after looking at blood tests and performing a physical exam. They may also perform anelectromyogram (EMG), which ...
Clinically, it was not possible to identify his as a sporadic instance of Becker muscular dystrophy (BMD) or one of spinal muscular atrophy. The problem arose because electromyography and elevated creatine kinase suggested a myopathy whereas changes in the muscle biopsy resembled a neurogenic disorder...
(FAPs), which were recently characterized as playing a role in muscle regeneration and repair processes. Indeed, FAPs differentiate into fibroblasts and adipocytes under pathological conditions, such as muscular dystrophy, leading to connective and fat tissue infiltration48. Similarly, the expression of...
Microgravity exposure can result in decreased muscle strength and endurance with a risk of muscle atrophy, which raises a major concern for astronauts on prolonged space missions70. To identify alterations in clock- and skeletal muscle- associated pathways due to spaceflight, we analysed omics datasets...