Muscle atrophyrefers to the shrinking or "wasting away" of muscles. It is usually a symptom of another condition rather than a condition in and of itself. In addition to a loss in the size of muscles, muscle atrophy can also cause muscle weakness. Muscular dystrophyis a rare genetic disorde...
Clinically, it was not possible to identify his as a sporadic instance of Becker muscular dystrophy (BMD) or one of spinal muscular atrophy. The problem arose because electromyography and elevated creatine kinase suggested a myopathy whereas changes in the muscle biopsy resembled a neurogenic disorder...
Fiber-type discrimination in disuse and glucocorticoid-induced atrophy. Med Sci Sports Exerc 1990; 22: 304–311. PubMed CAS Google Scholar Guerriero V, Florini JR. Dexamethasone effects on myoblast proliferation and differentiation. Endocrinology 1980; 106: 1198–1202. Article PubMed CAS Google ...
Clinically, it was not possible to identify his as a sporadic instance of Becker muscular dystrophy (BMD) or one of spinal muscular atrophy. The problem arose because electromyography and elevated creatine kinase suggested a myopathy whereas changes in the muscle biopsy resembled a neurogenic disorder...
muscle atrophy. However, other work shows estrogen treatment in female mice to have little effect on muscular deteriorations with disuse [147], suggesting that estrogen treatment in females is not sufficient to counteract disuse atrophy. Contrastingly, estrogen-based treatments (including both estrogen ...
Abstract The peculiar clinical features and the pathogenic mechanism related to calpain-3 deficiency (impaired sarcomere remodelling) suggest that the ubiquitin-proteasome degradation pathway may have a crucial role in Limb Girdle Muscular Dystrophy 2A (LGMD2A). We therefore investigated muscle atrophy and...
Our results indicate that the muscle-specific upregulation of caveolin 3 result in muscle atrophy, but not in muscular dystrophy. Further studies have been on going to explore the precise roles of caveolin 3 in the pathogenesis of muscular dystrophy....
myostatin antibody, RK35, OPMD, Muscle atrophyBackgroundOculopharyngeal muscular dystrophy (OPMD) is a late‐onset muscle disease affecting one per 80 000 of the general population characterized by profound dysphagia and ptosis, and limb weakness at later stages. Affected muscles are characterized by...
also skeletal muscle-associated genes like muscle atrophy associated gene activating transcription factor 4 (Atf4/ATF4) was downregulated in both spaceflight and aging datasets, while its expression in fasting and exercise conditions (depending on the type of exercise) was upregulated. Hence, insights ...
Passive stretching can also prevent the atrophy of myotubes, which normally occurs in culture media lacking growth factors. The mechanisms responsible for transduction of passive strain into a proliferative and/or trophic influence is unclear but may involve mediators such as PGF2α, insulin-like ...