Multiple system atrophy (MSA) is a rare neurodegenerative disease that is characterized by neuronal loss and gliosis in multiple areas of the central nervous system including striatonigral, olivopontocerebellar and central autonomic structures. Oligodend
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized by a variable combination of parkinsonism, cerebellar impairment, and autonomic dysfunction. The pathologic hallmark is the accumulation of aggregated α﹕ynuclein in oligodendrocytes, forming glial cytoplasmic ...
The Multiple-System Atrophy Research Collaboration. Mutations in COQ2 in familial and sporadic multiple-system atrophy.N. Engl. J. Med.369, 233–244 (2013).The first study to identify relevant functional mutations in theCOQ2gene that are associated with an increased risk of developing MSA. Wull...
Multiple system atrophy (MSA) carries a universallPoeweMedWernerMedKrismerMedFlorianMedNature reviews. NeurologyPoewe W, Krismer F. Neurodegenerative disease: Multiple system atrophy - new insight from prospective studies. Nat Rev Neurol. 2015;11:430-1....
Multiple system atrophy (MSA) is a heterogenous, uniformly fatal neurodegenerative ɑ-synucleinopathy. Patients present with varying degrees of dysautonomia, parkinsonism, cerebellar dysfunction, and corticospinal degeneration. The underlying pathophysio
Multiple system atrophy (MSA) is a devastating and fatal neurodegenerative disorder. The clinical presentation of this disease is highly variable, with parkinsonism, cerebellar ataxia and autonomic failure being the most common - and often debilitating - symptoms. These symptoms progress rapidly, and pa...
The meaning of MULTIPLE SYSTEM ATROPHY is any of several progressive neurodegenerative diseases that are of unknown cause, have an onset usually during middle age and are characterized by a combination of symptoms (as orthostatic hypotension, urinary inc
多系统萎缩(multiple system atrophy,MSA)是成年期发病的致命性神经退行性疾病。临床表现为进展性自主神经功能障碍,伴帕金森症状、小脑性共济失调症状及锥体束征为主要临床特征的神经系统退行性疾病。分为MSA-…
多系统萎缩(Multiple System Atrophy) 多系统萎缩于1969年被首次命名,是一种中老年起病,以进展性自主神经功能障碍,伴帕金森症状、小脑性共济失调性症状及椎体束为主要临床特征的神经系统退行性疾病。 编辑者:尹刘杰
Multiple system atrophy (MSA) is a devastating and fatal neurodegenerative disorder. The clinical presentation of this disease is highly variable, with parkinsonism, cerebellar ataxia and autonomic failure being the most common - and often debilitating - symptoms. These symptoms progress rapidly, and ...