There are many different strains of B. pseudomallei that have been isolated from patients with melioidosis, but it was not clear if they could cause a similar disease in a chronic BALB/c murine model of melioidosis. Hence, we wanted to examine chronically infected mice exposed to different ...
Unless otherwise explained, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The singular terms “a,”“an,” and “the” include plural referents unless context clearly indicates other...
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have usedin vivomurine models of MM to show significant induction of nerve growth factor (NGF) by the tumour...
Other possible methods for generating mutations include point mismatch repair (Kramer et al., Cell, 38: 879-887 (1984)), mutagenesis using repair-deficient host strains (Carter et al., Nucl. Acids Res., 13: 4431-4443 (1985)), deletion mutagenesis (Eghtedarzadeh and Henikoff, Nucl. Acids ...
of interest because this uniquely human change likely protects us from a variety of pathogens that selectively bind to α2–3-linked Sias, particularly avian influenza viruses [65]. Indeed human influenza virus strains bind preferentially to α2–6-linked Sias [66,67], a binding specificity ...
“Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting”, Proc. Natl. Acad. Sci. USA 103:6841-46, 2006. Rustandi et al. “The Ca2+-Dependent Interaction of S100B(ββ) with a Peptide Derived from p53”, ...
Unless otherwise explained, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The singular terms “a,”“an,” and “the” include plural referents unless context clearly indicates other...
Different strains of bacteria were already found to be enriched or depleted in MS cases compared to controls [194]. Further research is needed to clarify whether this imbalance is a cause or a consequence of MS and whether it is related to disease severity. TL has been associated with ...
As explained in “Selecting the most promising epitopes,” the epitopes with high antigenicity, an absence of allergies and toxicity, conservation across selected strains of gp120, the potential to provoke cytokines specifically for HTL epitopes, and non-similarity to the human proteome were identified...
In this study, we sequenced the whole genome of seven M. tuberculosis strains, including four extensively drug-resistant (XDR) and two pan-susceptible clinical isolates and M. tuberculosis H37Rv (ATCC 27294), using high-precision PacBio single-molecule real-time (SMRT) sequencing technology [10]...