Multiple sclerosis (MS) is a complex trait and highlights the interplay between nature, nurture and the stochastic events of development. Genetic-epidemiological studies have shown the importance of the genetic contribution to the marked familial clustering of MS. Environmental factors also increase MS ...
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated...
Multiple Sclerosis Genetics 来自 掌桥科研 喜欢 0 阅读量: 64 作者:JP Mcelroy,JR Oksenberg 摘要: Multiple sclerosis (MS) clusters with the so-called complex genetic diseases, a group of common disorders characterized by modest disease risk heritability and multifaceted gene-environment interactions. ...
Recently, the International Multiple Sclerosis Genetics Consortium provided evidence for three new loci that show significant association at a genome-wide level: RGS1, IL12A and MPHOSPH9/CDK2AP1. In this article, we will review the three newly discovered susceptibility loci and the implications of...
33. Huang J, Xie ZF: Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: a meta-analysis of case-control studies. J Neurol Sci... FC Top,P Make - 《Vitamindwiki Com》 被引量: 0发表: 0年 加载更多来源期刊 Genetics Home Reference 研究点推荐 Multiple sclerosis 站...
Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic genetic epidemiological and molecular genetic studies have provided important insights. Both genetic and non-genetic (environment, stochastic) factors may be involved in susceptibility as well as outcome, but we have yet to under...
This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.Similar content being viewed by others Towards a global view of multiple sclerosis genetics...
Chapter 9 Multiple sclerosis genetics Background: Matrix metalloproteinases (MMPs) play important role in Multiple Sclerosis (MS), an autoimmune and neuro-inflammatory disease. It has been demo... B Cree 被引量: 0发表: 2014年 The changing demographic pattern of multiple sclerosis epidemiology The ...
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predo
Multiple sclerosis genetics--is the glass half full, or half empty? Multiple sclerosis (MS) is a common and severe CNS disorder that is characterized by myelin loss, chronic inflammation, axonal and oligodendrocyte patholog... JR Oksenberg,SE Baranzini - 《Nature Reviews Neurology》 被引量: 183...