Genetic basis of multiple sclerosis: HLA antigens, disease progression, and oligoclonal IgG in CSF. Acta Neurol. Scand. 59:297-308.Stendahl-Brodin L, Link H, Möller E, Norrby E (1979) Genetic basis of multiple sclerosis: HLA antigens, disease progression, and oligoclonal IgG in CSF. ...
a, Risk ratio of SNPs for MS based on WAP (seeMethods) when decomposed by inferred ancestry. The mean and s.d. were calculated for each ancestry on the basis of bootstrap resampling for each chromosome (n = 408,884 individuals). The distribution of risk ratios for each ancestry is ...
Conclusions: Genetic basis of multiple sclerosis is still not fully elucidated. Further research may clarify our results and confirm the value of studied factors for clinical practice.doi:10.1515/acm-2017-0007Sandra HanysovaD. CiernyE. Kurca
Revealing the genetic basis of multiple sclerosis: are we there yet? For more than 30 years the only genetic factor associated with susceptibility to multiple sclerosis (MS) was the human leukocyte antigen (HLA) region. Rece... SE Baranzini - 《Current Opinion in Genetics & Development》 被引...
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated...
risk of developing multiple sclerosis. These variants map almost exclusively to regulatory regions of the genome that are active in immune cells suggesting that these variants primarily exert their effects by altering the expression of otherwise normal genes in critically important immune cell sub-types...
The hexanucleotide GGGGCC repeat expansion inC9orf72(chromosome 9 open reading frame 72, 9p21.2) is most commonly associated with amyotrophic lateral sclerosis and frontotemporal dementia [133,134,135], but has also been detected in rare cases of PD, Alzheimer’s Disease, psychosis and atypical ...
Current knowledge of the genetics of MSA is limited. To address this gap, we provide a concise review of published literature on genetic risk factors and potential pathogenic genes and loci linked to both sporadic and familial MSA, and outline the biological basis and evidence that support the ...
An international team of researchers led by Karolinska Institutet in Sweden reports that cells in the central nervous system known as oligodendrocytes might have a different role in the development of multiple sclerosis (MS) than previously thought. The findings, published in the journalNeuron, could...
Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy in SNPs associated with SCZ (=21856) and multiple sclerosis (MS) (=43879), an inflammatory, demyelinating disease of the central nervous system. Because SCZ and bipolar disorder (BD) show substantial clinical and ...