Leukemia, Plasma CellAntigens, CDMultiple MyelomaBetween October 1988 and October 1991, 104 patients with multiple myeloma and 6 with plasma cell leukaemia were studied cytogenetically. Abnormal karyotypes were found in bone marrow cells of 33 patients (30%). Most pathological karyotypes were ...
Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. First described in 1848, MM is characterized by a proliferation of malign
Extramedullary multiple myeloma. Leuk Lymphoma. 2013;54:1135–41. PubMed Google Scholar Fernandez de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the...
Multiple myeloma (MM) is a biologically and clinically heterogeneous malignancy of terminally differentiated plasma cells (PCs), which abnormally proliferate in the bone marrow (BM), and typically secrete non-functional monoclonal immunoglobulin (Ig) in serum and urine. The stages of MM development us...
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a ...
8. Immunoglobulin E (IgE) Myeloma IgE is the rarest type of multiple myeloma. It causes the same signs and symptoms as other types of multiple myeloma. It tends to be aggressive and progresses to plasma cellleukemiaor spreads outside the bone marrow quickly....
10. Kaiser MF, Hall A, Walker K, et al: Depth of response and minimal residual disease status in ultra high-risk multiple myeloma and plasma cell leukemia treated with daratumumab, bortezomib, lenalidomide, cyclophosphamide and dexamethasone: Results of the UK OPTIMUM/MUKnine trial.2021 ASCO Annu...
The Ig heavy chain is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood 1997; 90: 526–534. CAS PubMed Google Scholar Fonseca R, Oken MM, Harrington D, Bailey RJ, Van Wier SA, Henderson KJ et al. ...
Multiple myeloma 20 30.67 0.65 (0.40, 1.01) 0.055 All Leukemia 53 67.13 0.79 (0.59, 1.03) 0.088 Abbreviations: CI, confidence interval; SIR, standardized incidence ratio; SMR, standardized mortality ratio. a Adjusted for age and calendar year at risk by stratification. b The number of observed...
Multiple myeloma (MM), although a rare disease, is the second most common hematologic malignancy. It is found in the spectrum of plasma cell dyscrasias, which begins with monoclonal gammopathy of unknown significance (MGUS) to overt plasma cell leukemia and extramedullary myeloma. MM is associated...