Multiple myeloma is a common cause of chronic kidney disease (CKD). Patients with myeloma-related kidney disease but low levels of serum monoclonal proteins can be diagnosed with symptomatic myeloma in a simplified diagnostic classification. The presence and type of renal disease in myeloma is ...
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Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populat
Multiple myeloma is a common cause of chronic kidney disease (CKD). Patients with myeloma-related kidney disease but low levels of serum monoclonal protein... JG Penfield 被引量: 44发表: 2006年 Bisphosphonates in oncology: physiopathologic bases and clinical activity. multiple myelomanew bisphosphona...
For Multiple Myeloma (MM), better anti-MM therapies need to be developed in order to treat refractory, relapsed, and newly diagnosed MM. Recently, Histone deacetylase inhibitors (HDACIs) as a combined drug with bortezomib have been evaluated for the treatment of MM. In this study, we examined...
Association of Serum Free Light Chain Level with Long-Term Kidney Function in Patients with Newly Diagnosed Multiple Myeloma Introduction: Multiple myeloma (MM) frequently involves the kidneys, resulting in acute, subacute, or chronic kidney disease (CKD). Patient- and treatment-... Paolo Lopedote...
1966 patients with newly diagnosed symptomatic MM were recruited in the MRC Myeloma IX trial; 1112 (56.6%) were assigned to the intensive arm and 854 (43.4%) to the non-intensive arm of the trial (Fig. 1). Renal function from samples sent for central laboratory analysis at diagnosis were...
BACKGROUND: The International Staging System (ISS) is the most widely used staging system for patients with multiple myeloma (MM). However, serum β2-microglobulin increases in renal impairment (RI) and there have been concerns that ISS-3 stage may include 'up-staged' MM patients in whom ele...
Multiple myeloma management requires a balance between maximizing survival, minimizing adverse events to therapy, and monitoring disease progression. While previous work has proposed data-driven models for individual tasks, these approaches fail to provi
VRD regimen has good efficacy and safety, and can improve renal function to a certain extent. Keywords: newly diagnosed multiple myeloma / lenalidomide / bortezomib / dexamethasone / efficacy / safety 多发性骨髓瘤(multiple myeloma,MM)是一种克隆性浆细胞疾病,随着蛋白酶体抑制剂、免疫调节剂、自体...