Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the ...
In addition, the M proteins produced by cancerous plasma cells can accumulate in the kidneys and impair kidney function. People with multiple myeloma are also at increased risk of infection due to immune dysfunction. How Common Is Multiple Myeloma? Multiple myeloma is diagnosed in about 35 000...
Differential progression of renal scarring and determinants of late renal recovery in sustained dialysis dependent acute kidney injury secondary to myeloma kidney. J Clin Pathol 2010; 63: 884–887. Article PubMed Google Scholar Batuman V, Verroust PJ, Navar GL, Kaysen JH, Goda FO, Campbell ...
Multiple myeloma (MM) has a high incidence rate in the elderly. Responsiveness to treatments differs considerably among patients because of high heterogeneity of MM. Chronic kidney disease (CKD) is a common clinical feature in MM patients, and treatment-related mortality and morbidity are higher in...
Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells originate from plasma cells in the bone marrow, and plasma cells are cells that develop to the final stage of function of B lymphocytes. Therefore, multiple myeloma can be classified as B lymphocyte lymphoma. The WH...
normal kidney function, (3) treatment-induced myelosuppression or myelodysplasia, (4) autoimmune hemolysis, (5) hemodilution, (6) high marrow levels of IL-6 that can suppresses erythropoiesis, and (7) the many usual causes of anemia in individuals of the same demographics as myeloma patients....
The introduction of several novel therapeutic agents has improved the outcome in multiple myeloma (MM) patients including those with chronic kidney disease, and it is predicted that MM will become a curable disease in a substantial subset of MM patients. While in the past—because of in...
Diagnostic testing at the Myeloma Center may include: Complete Blood Profile identifies counts of white cells, red cells and platelets and other indicators of blood composition. Blood profile results can indicate the quality of bone marrow, kidney function and liver function. ...
Different blood, urine, and bone marrow tests help diagnose multiple myeloma, and determine treatment. WebMD explains what you can expect from each from each type of test and what to expect next.
and complications include severe bone pain,pathologic fractures,osteoporosis,hypercalcemia, renal insufficiency (the so-called “myeloma kidney”),anemiaand, more infrequently,spinal cord compression, andperipheral neuropathy(Bladé and Rosiñol, 2007; Edwards et al., 2008). In addition,multiple myeloma...