Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the ...
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populat
In addition, the M proteins produced by cancerous plasma cells can accumulate in the kidneys and impair kidney function. People with multiple myeloma are also at increased risk of infection due to immune dysfunction. How Common Is Multiple Myeloma? Multiple myeloma is diagnosed in about 35 000...
Assistant Member in the Myeloma Section Malignant Hematology Department Moffitt Cancer Center & Research Institute Tampa, FL CASE SUMMARY A 70-year-old White woman was diagnosed with stage I multiple myeloma. She had a medical history including stage 3 chronic kidney disease and mild renal impairment...
What are the signs of multiple myeloma? Early-stage signs are vague and mimic many other issues, notes the MMRF, but can include anemia, bone damage, lessened immunity, decreased kidney function, and high levels of calcium in the blood, all of which can be detected through urine and blood...
Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells originate from plasma cells in the bone marrow, and plasma cells are cells that develop to the final stage of function of B lymphocytes. Therefore, multiple myeloma can be classified as B lymphocyte lymphoma. The WH...
One year later (2022), a second relapse was discovered, and kidney function continued to decline. DISCUSSION QUESTION What regimens do the National Comprehensive Cancer Network (NCCN) guidelines suggest for patients with multiple myeloma refractory to multiple lines of therapy, and how do ...
and complications include severe bone pain,pathologic fractures,osteoporosis,hypercalcemia, renal insufficiency (the so-called “myeloma kidney”),anemiaand, more infrequently,spinal cord compression, andperipheral neuropathy(Bladé and Rosiñol, 2007; Edwards et al., 2008). In addition,multiple myeloma...
One or more myeloma-defining events. Myeloma-defining events include the following [141] : Hypercalcemia: Serum calcium level > 1 mg/dL (> 0.25 mmol/L) higher than the upper limit of normal or > 2.75 mmol/L (> 11 mg/dL) Abnormal kidney function: Serum creatinine > 2 mg/dL (> ...
The treatment was very effective, and hemodialysis was stopped. Nineteen months after the primary therapy, he has been continuing chemotherapy in another hospital, with good ADL. 展开 关键词: multiple myeloma primary symptom mandible acute kidney injury hemodialysis ...