KidneysMultiple myeloma (MM) is the abnormal proliferation of plasma cells that leads to the production of monoclonal light chains. These light chains may cause renal disease by forming tubular casts (cast neph
Multiple myeloma (MM) has a high incidence rate in the elderly. Responsiveness to treatments differs considerably among patients because of high heterogeneity of MM. Chronic kidney disease (CKD) is a common clinical feature in MM patients, and treatment-related mortality and morbidity are higher in...
Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells in the bone marrow and the production of monoclonal immunoglobulin, also known as M protein [1]. This leads to various clinical manifestations, such as anemia, lytic bone lesions, hypercalcemi...
When you have myeloma, your body produces a lot of weak antibodies that crowd out healthy ones, making it harder for you to fight infection. A lack of white blood cells can also weaken your immune system. Kidney damage. Myeloma can clog your kidneys so they don't filter the way they sh...
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populat
Multiple myeloma (MM) is an immune system disease characterized as a progressive and incurable hematological neoplasia of B lymphocytes caused by an unregulated and clonal proliferation of plasmacytes in the bone marrow (BM). From: Hematology, Transfusion and Cell Therapy, 2021 ...
In addition, the M proteins produced by cancerous plasma cells can accumulate in the kidneys and impair kidney function. People with multiple myeloma are also at increased risk of infection due to immune dysfunction. How Common Is Multiple Myeloma? Multiple myeloma is diagnosed in about 35 000...
Kidneys:Multiple myeloma and high levels of calcium can hurt your kidneys and make it harder for them to filter your blood. Your body might not be able to get rid of extra salt, fluid, and waste. This can make you: Weak Short of breath ...
Dietary and Lifestyle Considerations Nutrients Updated History References 1 Introduction Multiple myeloma (MM) is a cancer of mature plasma cells, which are a type of white blood cell that produces immunoglobulins (antibodies). Antibodies are normally produced to protect the body from microbes, such...
Jin Yuan2, Yilu Xu1, Yaping Zhang1, Ligen Liu 1, Aibin Liang 3 ✉, Zhuo Yu1 ✉ and Junke Zheng 1,4 ✉ © The Author(s) 2024 Although multiple myeloma (MM) responds well to immunotherapeutic treatment, certain portions of MM are still unresponsive or relapse after immunotherapy....