KidneysMultiple myeloma (MM) is the abnormal proliferation of plasma cells that leads to the production of monoclonal light chains. These light chains may cause renal disease by forming tubular casts (cast nephropathy), granular deposits (light chain deposition disease), or amyloid (AL amyloidosis)...
8.6K Multiple myeloma is a cancer that attacks plasma cells in bone marrow, reducing the body's ability to fight infections. Learn about multiple myeloma, including the cells involved, tests, and treatments. Explore related conditions and understand which symptoms indicate multiple myeloma. Related...
The blood and kidneys are normal, and there is no bone damage. People who have smoldering myeloma often do not need treatment right away. Stage I: There aren't that many myeloma cells in the body. Doctors can't see any bone damage on X-rays, or the cancer has damaged only one area...
In addition, the M proteins produced by cancerous plasma cells can accumulate in the kidneys and impair kidney function. People with multiple myeloma are also at increased risk of infection due to immune dysfunction. How Common Is Multiple Myeloma? Multiple myeloma is diagnosed in about 35 000...
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populat
Myeloma kidney (monoclonal antibodies collect in the kidneys, which can interfere with kidney function) Kidney stones (from an increase in uric acid caused by the growth of cancerous cells) Kidney failure Amyloidosis (the build-up of proteins called amyloid in the kidneys, liver, and other organ...
Multiple myeloma (MM) is an immune system disease characterized as a progressive and incurable hematological neoplasia of B lymphocytes caused by an unregulated and clonal proliferation of plasmacytes in the bone marrow (BM). From:Hematology, Transfusion and Cell Therapy,2021 ...
Infections.When you have myeloma, your body produces a lot of weak antibodies that crowd out healthy ones, making it harder for you to fight infection. A lack of white blood cells can also weaken your immune system. Kidney damage.Myeloma can clog your kidneys so they don't filter the way...
Myeloma proteins can also collect in the tubules of the kidney and cause renal failure. In addition, bone destruction that releases calcium into the circulation may result in calcium deposition in the kidneys and other abnormal sites. Symptoms and signs of multiple myeloma include pain, anemia, ...
Dietary and Lifestyle Considerations Nutrients Updated History References 1 Introduction Multiple myeloma (MM) is a cancer of mature plasma cells, which are a type of white blood cell that produces immunoglobulins (antibodies). Antibodies are normally produced to protect the body from microbes, such...