Multiple myeloma (MM) is characterised by bone degradation and suppression of the immune system. It often presents itself as bone pain and anaemia. Coexistence of Pott's disease and TB is a rare occurrence. However, we present a patient with persistent back pain and anaemia, who was initially...
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induc
The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions between MM cells and the bone marrow (BM) microenvironment, including the BM ECM, ...
The meaning of MULTIPLE MYELOMA is a disease of bone marrow that is characterized by the presence of numerous myelomas in various bones of the body.
Multiple Myeloma Presenting with Crystal Deposition in the Bone MarrowLight and heavy chain deposition diseasesmyelomatosisamyloidosisparaproteinemiaMonoclonal immunoglobulin deposition disease (MIDD) is characterized by the deposition of amorphous non-congophilic materials predominantly in the kidneys leading to...
Multiple myeloma (MM) is an immune system disease characterized as a progressive and incurable hematological neoplasia of B lymphocytes caused by an unregulated and clonal proliferation of plasmacytes in the bone marrow (BM). From:Hematology, Transfusion and Cell Therapy,2021 ...
The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and extracellular vesicles. Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell...
Novel targeted therapies and combinations for the treatment of multiple myeloma. cells and the interaction between myeloma cells and elements of the bone marrow microenvironment that sustain proliferation and survival has significantly ... Amit,Agarwal,Daruka,... - 《Cardiovascular & Hematological Disorder...
(1984), BONE MARROW PLASMA CELL INFILTRATION IN MULTIPLE MYELOMA. British Journal of Haematology, 57: 352–353. doi: 10.1111/j.1365-2141.1984.tb02906.x Author Information Institute of Haematology ‘Lorenzo e Ariosto Seràgnoli’, S. Orsola's Hospital, University of Bologna, and Chair of ...
The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical trials. We evaluated whether circulating cell-free DNA (cfDNA) analysis is comparable to molecular profiling of myeloma using bone-marrow tumour cells...