There are a multitude of factors involved in promoting bone disease in MM; however, what remains unanswered is why patients in complete remission from MM are unable to heal their bone lesions. We hypothesize that MM cells exert a permanent change in the bone marrow microenvironment, either ...
Nature Reviews Cancer volume 7, pages 585–598 (2007)Cite this article 12k Accesses 760 Citations 20 Altmetric Metrics details Key Points Multiple myeloma is a currently incurable B-cell malignancy characterized by excess monotypic plasma cells in the bone marrow in association with an excess of ...
Multiple myeloma is a disease of the elderly. The process of aging leads to degenerative changes in several parts of the body. Rapidly dividing cells, like that of bone marrow, have to constantly replicate their DNA (genetic material), which is a complex process. Mistakes in this complex proc...
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow (BM), whereby the malignant plasma cells ...
The meaning of MULTIPLE MYELOMA is a disease of bone marrow that is characterized by the presence of numerous myelomas in various bones of the body.
The Pharmacy Times® Multiple Myeloma Resource Center is a comprehensive resource for clinical news and expert insights on issues related to cancer that forms in a type of white blood cell.
Multiple myeloma is a cancer of plasma cells from bone marrow. It is not really responding to standard chemotherapies. Nearly 86,000 patients are diagnosed with myeloma each year, and the number may continue to increase as the world population is aging. The disease usually occurs above 60 year...
6. Smoldering Multiple Myeloma (SMM) This is a precancerous form of myeloma. Like MGUS, there usually aren't symptoms. People with smoldering multiple myeloma have more M proteins in theirbloodor more myeloma plasma cells in their bone marrow. As a result, they're more likely to get activ...
Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failure of immunotherapies. Therefore, enhanced knowledge about the actual stat...
Molecular Cancer 2010 Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells DOI: 10.1186/1476-4598-9-176 Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim...