Multiple Myeloma or simply myeloma (in GreekMyelosmeans bone marrow), is known as one of the most devastating cancers affecting humans. Every year around 15,000 people are diagnosed with multiple myeloma in the United States. Survival for a period of 5 years is seen in only 50% people. Ge...
MM is the most common cancer metastasizing to bone, with 85鈥 90% of patients developing bone disease. It is unique from other forms of metastatic bone disease, as it is purely lytic. There are a multitude of factors involved in promoting bone disease in MM; however, what remains ...
000.1It is a clinically and biologically heterogeneous cancer arising from bone marrow plasma cells that evolves from a premalignant precursor condition (monoclonal gammopathy of undetermined significance) intoasymptomatic myelomaand, finally, symptomatic disease.2Uncontrolled myeloma frequently...
Nature Reviews Cancer volume 7, pages 585–598 (2007)Cite this article 12k Accesses 760 Citations 20 Altmetric Metrics details Key Points Multiple myeloma is a currently incurable B-cell malignancy characterized by excess monotypic plasma cells in the bone marrow in association with an excess of ...
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow
Credit: Pixabay/CC0 Public Domain Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed cancers but resistance or intolerance ...
Cancer-cell-biomimetic Nanoparticles for Targeted Therapy of Multiple Myeloma Based on Bone Marrow Homing. 来自 EBSCO 喜欢 0 阅读量: 162 作者:Y Qu,B Chu,X Wei,Y Chen,Y Yang,D Hu,J Huang,F Wang,M Chen,Y Zheng 摘要: Multiple myeloma (MM) is the second most common hematological ...
Multiple myeloma is a type ofblood cancerwhereimmune cellsgrow in an uncontrolled way in thebone marrow. Thediseaseis very difficult to treat and is still considered incurable, and thus it is urgent to identify new therapeutic targets in thecancer cells. ...
Correspondence04 Oct 2024Bone Marrow Transplantation P: 1-4 Characterization ofMYCRearrangements in Multiple Myeloma: an Optical Genome Mapping Approach Jung Yoon Taesung Jeon Soo-Young Yoon CorrespondenceOpen Access20 Sept 2024Blood Cancer Journal ...
Molecular Cancer 2010 Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells DOI: 10.1186/1476-4598-9-176 Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim...