Multiple Myeloma Multiplemyelomais amalignancyof plasma cells, which are derived fromB lymphocytes(B cells) and are responsible for creating antibodies. The disease is characterized by infiltration of themyeloma cellsinto the bone and, eventually, other organs. These malignant cells produce monoclonal (...
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. [1] First described in 1848, MM is part of...
The case herewith reported is of special significance since bone marrow plasma cells were found in the circulating blood by one of us, a condition rarely seen. An examination of the literature for the history of cases of multiple myeloma makes it evident that the disease, although rare, has ...
浆细胞病(Plasma cell dyscrasias) 多发性骨髓瘤(Multiple Myeloma)定义和特性;What Is Multiple Myeloma?;浆细胞病(Plasma cell dyscrasias);隐性浆细胞病良性单克隆免疫球蛋白血症;继发性单克隆免疫球蛋白血症。病因:尚未完全明了可能与遗传有关,有染色体异常病毒感染继发于其他疾病(慢性骨髓炎、结核、慢性肝炎);M...
Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, ... Multiple myeloma (MM) cells inhibit certain T-cell functions. We examined the expression of B7-H1 (PD-L1), a B7-related ...
Multiple myeloma (MM) is the second most common hematological malignancy in the US1, characterized by the clonal expansion of plasma cells localized primarily in the bone marrow microenvironment of the skeleton2,3. In the bone microenvironment, MM cells disrupt the finely tuned balance of trabecular...
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by immunosuppression. In this study, we identified factors in patients’ bone marrow (BM) sera inhibiting autologous anti-MM immunity and developed an ex vivo strategy for inducing MM-specific cytotoxic T lymphocytes (CTLs)....
Multiple myeloma: circulating lymphocytes that express plasma cell antigens. The bone marrow and peripheral blood of 14 patients with multiple myeloma were studied with murine monoclonal antibodies that identify antigens on plasma cells (R1-3 and OKT10). Peripheral blood lymphocytes expressing plasma ...
Multiple myeloma is a plasma cell malignancy characterized by recurrent IgH translocations and well described genomic heterogeneity. Although transcriptome profiles in multiple myeloma has been described, landscape of expressed fusion genes and their cli
We report a case of acute leukaemia occurring early in the course of IgA multiple myeloma. Ultrastructural studies, immunophenotyping and karyotyping were required to identify the origin and clonality of the leukaemic cells. Although ultrastructural examination of the blast cells revealed both monocytoid...