BCL2 family proteinsJAK2V617Fmouse modelsmyeloproliferative neoplasmsSeveral lines of research suggest that BCL-XL-mediated anti-apoptotic effects may contribute to pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in JAK2V617F ...
The Roles of the Bcl-2 Family Proteins in T Lymphocyte Development and Homeostasis proapoptotic members of the Bcl-2 family, the specific interactions by which Mcl-1 in particular promotes T cell survival in vivo were not well ... DH Dunkle - 《Dissertations & Theses Gradworks》 被引量: 0...
The expression and functions of integrin β1 in various cancer types were summarized in Table 2. Among these, the intriguing roles of integrin β1, in combination with distinct α subunits, are clarified as follows. Table 1 Signaling pathways mediated by integrin β1 with distinct α subunits ...
Background: The BAG (Bcl-2 associated athanogene) family is a multi-functional group of proteins that perform functions ranges from apoptosis to environmental stress tolerance. The BAG proteins are found in yeast, plants and animals. In plants, especially in Arabidopsis thaliana (Arabidopsis), BAG...
CTZ regulates expression of apoptosis proteins in MM.1S and NCI-H929 cells Apoptosis, triggered by drugs, is a critical mechanism for cancer cell extinction22, and Bax and Bcl-2 are key mediators of apoptosis23. Western blot analysis demonstrated that CTZ dose-dependently raised the levels of ...
The other 2 anchor proteins Num1 and Mdm36 are unique with dual functions: they connect Dnm1 to mitochondria and they regulate both mitochondrial division and positioning within the cell [33], [34], [35], [36]. In additional studies of Dmn1 in Caenorhabditis elegans, overexpression of wild...
Multi-omics approaches have also been used to assess CLL chemoresistance. The results of a single-cell multi-omics study by Thijssen et al. [138] suggest that venetoclax resistance in CLL is multi-layered. This is in part attributed to mutations in the BCL2 family, which act as apoptosis ...
At the molecular level, proteins residing in different organelles can interact and facilitate the formation of multi-organellar domains with new properties and functions. The distance between the ER and mitochondria was originally estimated to be approximately 100 nm [3], but later, high speed ...
In most cells, both Bid and Bax are cytoplasmic but bind to mitochondrial outer membranes to exert pro-apoptotic functions. Binding to membranes is regulated by cleavage of Bid to truncated Bid (tBid), by conformation changes in tBid and Bax, and by interactions with other proteins. At ...
This study aimed to investigate the potential involvement of SRD5A1 during MM pathogenesis, and the evidence from in vivo and in vitro data demonstrated that SRD5A1-mediated MM cell autophagy via PI3K/Akt/mTOR signaling pathway and induced MM cell apoptosis through Bcl-2 proteins family in MM. ...