How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res. 2006;16(2):203 -213.van Delft MF,Huang DC.How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Research . 2006van Delft MF,Huang DC.How the Bcl-2 family of proteins interact to regulate ...
Elizabeth J Osterlund1,2 and David W Andrews*,1,2,3 The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activ...
[3] Shamas-Din A, Kale J, Leber B, Andrews DW. Mechanisms of action of Bcl-2 family prote...
BCL-2 family proteins, which have either pro- or anti-apoptotic activities, have been studied intensively for the past decade owing to their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. They control the point of no return for clonogenic ce...
The proteins of the Bcl-2 family are important regulators of programmed cell death. Structural studies of Bcl-2 family members have provided many important insights into their molecular mechanism of action and how members of this family interact with one another. To date, structural studies have ...
In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL鈥 2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting ...
Overexpression of pro-survival BCL-2 family regulator proteins is an important driver of resistance to cell death in a heterogeneous disease4 PRO-SURVIVAL REGULATOR PROTEINS Some include BCL-2, BCL-XL, and MCL-1, all of which play a key role in regulating apoptosis.2,4 ...
Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, contributing to neoplastic cell expansion by suppressing programmed cell death and extending tumor ...
Bcl-2 family proteins play key roles in tumor initiation, progression, and resistance to therapy. Therefore, the protein-protein interactions (PPIs) between the pro-survival proteins, B-cell lymphoma (Bcl)-2 and Bcl-xL, and the pro-apoptotic proteins, Bax and Bak, could be attractive therapeu...
1999. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487.Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC... S Shimizu,M Narita,Y Tsujimoto,... - 《Nature》 被...