BCL-2 proteins are a family of pro- and anti-apoptotic proteins that regulate a critical step in the mitochondrial apoptotic pathway, the permeabilization of the mitochondrial outer membrane. Because apoptosis and mitochondrial function play an important role in physiology and a number of diseases, ...
BCL-2 家族蛋白质的相互作用抗凋亡蛋白（Anti-apoptotic proteins）Bcl-2抗凋亡亚家族是Bcl-2蛋白家族中...
The BCL-2 family is functionally grouped into proteins that repress apoptosis, BCL-2, BCL-XL, BCL-w, MCL-1, and A1, and the proteins that promote apoptosis (pro-apoptotic) (23). The pro-apoptotic members are further subdivided into two groups, the BAX/BAK subfamily and the BH3-only ...
Dancing is a joy of life; however, cells have a dance between the BCL-2 family proteins that can lead to death. Exchange of dance partners within the BCL-2 family proteins regulates apoptosis. The outcome of this dance – the fate of the cell – is decided by the net interactions betwee...
7. BCL-2 family proteins: changing partners in the dance towards death. Kale J, Osterlund EJ, Andrews DW. Cell Death Differ. 2018 Jan;25(1):65-80. doi:10.1038/cdd.2017.186. 8. https://www.onclive.com/publicat...
Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells 通讯作者(Correspondence):Jonathan A. Garlick Research:…
The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the ...
BCL-2 family proteins, which have either pro- or anti-apoptotic activities, have been studied intensively for the past decade owing to their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. They control the point of no return for clonogenic ce...
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399 (6735), 483-487.Shimizu S,Narita M,Tsujimoto Y.Bcl-2 family proteins regulate the releases of apoptogenic cytochrome ... S Shimizu,M Narita,Y Tsujimoto,... - 《Nature》 被...
3.1 Bcl2 family of proteins The Bcl2 family of proteins can be broadly categorized into 2 groups: pro-apoptotic and anti-apoptotic. All Bcl2 family members have certain sequence homology domains, termed Bcl2 homology (BH) domains. There are currently 4 known BH domains. The anti-apoptotic pr...