Multiple system atrophy (MSA) is recognized as an atypical Parkinsonian syndrome, distinguished by a more rapid progression than that observed in Parkinson's disease. Unfortunately, the prognosis for MSA remains poor, with a notable absence of globally recognized effective treatments. Although ...
A common source of misdiagnosis of PD is atypical parkinsonian syndromes (APS) that have a much poorer long-term prognosis such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In a clinico-pathological study conducted in a specialist ...
Brooks DJ, Ibanez V, Sawle GV, Quinn N, Lees AJ, Mathias CJ et al (1990) Differing patterns of striatal18F-dopa uptake in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Annals Neurology 28 (4):547–555. https://doi.org/10.1002/ana.410280412 Article Goog...
Additionally, using proteomics analysis of human CRC samples, we identified links between gut aging and CRC, with high HPX levels predicting poor prognosis in older patients with CRC. Together, this work provides potential targets for preventing gut aging and associated diseases....
Treatment and Prognosis Praziquantel or epsiprantel are effective for treatment ofTaeniaspp. infections using the same dosages as used forD. caninum(Table 115.3).23In the USA, fenbendazole is approved at 50 mg/kg q24h for 3 consecutive days forT. pisiformisin dogs; in the UK, the same ...
In familial FTD, atrophy patterns vary by genotype between carriers ofC9orf72,GRN,andMAPTvariants [77]. For these mutation carriers, Staffaroni et al. predicted symptom onset using a joint Bayesian mixed effects model of longitudinal clinical assessments, regional brain volume, and plasma neurofilam...
Taenia multiceps is a taeniid cestode that inhabits the small intestines of both wild and domestic carnivores. The larval stage, Coenurus cerebralis, is typically found in the central nervous system (CNS) of a wide range of livestock and, to a lesser ext
It can also be used to treat motoneuron disorders, such as amyotrophic lateral sclerosis (Lou Gehrig's disease), Bell's palsy, and various conditions involving spinal muscular atrophy, or paralysis. The agonist antibody can be used to treat human “neurodegenerative disorders”, such as Alzheimer...
Therefore, for the future development of new treatment approaches, such as gene therapy, as well as the establishment of novel biomarkers to improve differential diagnosis, prognosis and therapy monitoring of Duchenne muscular dystrophy, both multi-system pathology and organ crosstalk should be taken ...
In all, scTCR-seq and associated analyses enhance the exploration and application of TCR sequencing. They facilitate the exploration of mechanisms, helping cancer early-stage diagnosis, treatment selection, and prognosis prediction, and designing engineering therapeutic strategies. ...